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25843-45-2

中文名稱 偶氮甲烷
英文名稱 AZOXYMETHANE
CAS 25843-45-2
分子式 C2H6N2O
分子量 74.08
MOL 文件 25843-45-2.mol
更新日期 2024/05/28 16:04:18
25843-45-2 結(jié)構(gòu)式 25843-45-2 結(jié)構(gòu)式

基本信息

中文別名
偶氮甲烷
氧化偶氮基甲烷
AOM氧化偶氮甲烷
偶氮甲烷(AOM)
結(jié)腸癌造模誘導(dǎo)劑氧化偶氮甲烷
PERFEMIKER]氧化偶氮甲烷,95%
英文別名
AOM
AZOXYMETHANE
azoxy-methan
CH3N=N(→O)CH3
Methane, azoxy-
ONN-Azoxydimethane
Dimethyldiazene 1-oxide
Azoxymethane DISCONTINUED
1,2-Dimethyldiazene 1-oxide
(Z)-1,2-diMethyldiazene oxide

物理化學(xué)性質(zhì)

沸點97-99 °C(lit.)
密度0.991 g/mL at 25 °C(lit.)
折射率1.4368 (estimate)
閃點24 °C
儲存條件−20°C
溶解度Soluble in water, ethanol, and ether
形態(tài)Liquid
比重0.991
顏色Oil
InChIInChI=1S/C2H6N2O/c1-3-4(2)5/h1-2H3
InChIKeyDGAKHGXRMXWHBX-UHFFFAOYSA-N
SMILES[N+]([O-])(C)=NC
EPA化學(xué)物質(zhì)信息Azoxymethane (25843-45-2)

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS02,GHS06,GHS08
警示詞危險
危險品標志T
危險類別碼45-46-10-25-34-36/38
安全說明53-26-36/37/39-45
危險品運輸編號UN 1992 3/PG 3
WGK Germany3
RTECS號PA2975000
毒性mma-sat 13,600 mmol/L/20M CNREA8 38,4585,78

上下游產(chǎn)品信息

下游產(chǎn)品
頭孢呋辛

常見問題列表

生物活性
Azoxymethane 是一種結(jié)腸致癌物質(zhì),可導(dǎo)致 DNA 加合物的形成。
體外研究

Azoxymethane is a colon carcinogen which leads to the formation of DNA adducts. On an equal protein basis, hepatic microsomes are much more active than SI and colon microsomes in NADPH-dependent Azoxymethane bioactivation and N 7 -mG adduct formation. Hepatic microsomes show the highest activity in the hydroxylation of Azoxymethane, followed by SI and colon microsomes.

體內(nèi)研究

Regardless of the strain, the amounts of O 6 -mG and N 7 -mG produced by Azoxymethane are highest in the liver, followed by proximal and distal colons, which have similar levels, and then by duodenum, jejunum and ileum. Results indicate that the Azoxymethane-induced DNA adduct formation in the SI and colon does not depend on bioactivation by hepatic P450 enzymes. Irrespective of the mouse strain, no aberrant crypt foci (ACF) is detected in the colons of saline-treated mice; in contrast, colonic ACF is detected in all three strains of Azoxymethane-treated mice. The Azoxymethane-treated athymic mice have approximately an 11-fold lower tumor incidence than similarly treated WT animals.

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