245075-84-7
245075-84-7 結(jié)構(gòu)式
基本信息
2,2'-((((((亞甲基雙(2-氯-4,1-亞苯基))二(氮烷二基))二(羰基))雙(氮烷二基))二(4,1-亞苯基))二( 氧基))雙(2-甲基丙酸)
2,2'-{Methylenebis[(2-chloro-4,1-phenylene)carbamoylimino-4,1-phenyleneoxy]}bis(2-methylpropanoic acid)
2,2-[Methylenebis[(2-chloro-4,1-phenylene)iminocarbonylimino-4,1-phenyleneoxy]]bis[2-methylpropanoic acid]
Propanoic acid, 2,2'-[methylenebis[(2-chloro-4,1-phenylene)iminocarbonylimino-4,1-phenyleneoxy]]bis[2-methyl-
2,2'-((((((methylenebis(2-chloro-4,1-phenylene))bis(azanediyl))bis(carbonyl))bis(azanediyl))bis(4,1-phenylene))bis(oxy))bis(2-methylpropanoic acid)
2,2'-(4,4'-(4,4'-Methylenebis(2-chloro-4,1-phenylene))bis(azanediyl)bis(oxoMethylene)bis(azanediyl)bis(4,1-phenylene))bis(oxy)bis(2-Methylpropanoic acid)
物理化學(xué)性質(zhì)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-76383 | 2,2' - ((((((亞甲基雙(2-氯-4,1-亞苯基))二(氮烷二基))二(羰基))雙(氮烷二 LR-90 | 245075-84-7 | 5mg | 1800元 |
| 2024/11/08 | HY-76383 | 2,2' - ((((((亞甲基雙(2-氯-4,1-亞苯基))二(氮烷二基))二(羰基))雙(氮烷二 LR-90 | 245075-84-7 | 10mM * 1mLin DMSO | 2810元 |
| 2024/11/08 | HY-76383 | 2,2' - ((((((亞甲基雙(2-氯-4,1-亞苯基))二(氮烷二基))二(羰基))雙(氮烷二 LR-90 | 245075-84-7 | 10mg | 3000元 |
常見問題列表
AGE
LR-90 (0, 25, 50, 100, and 200 μM) inhibits RAGE, MCP-1, COX-2, IP-10 and NOX2 mRNA expression in THP-1 cells in a dose-dependent manner, after pretreatment 1 h befor S100b stimulatation for 4 hours.
LR-90 (0, 25, 50, 100, and 200 μM) dose-dependently and significantly blocks THP-1 cells adherence to endothelial cells after pretreatment 1 h befor S100b stimulatation for 24 hours.
LR-90 (0, 25, 50, 100, and 200 μM, for 24 hours) shows no effect on the cell viability of THP-1 cells.
Cell Viability Assay
| Cell Line: | THP-1 cells |
| Concentration: | 0, 25, 50, 100, and 200 μM |
| Incubation Time: | 24 hours |
| Result: | Showed no cytotoxicity to THP-1 cells. |
RT-PCR
| Cell Line: | THP-1 cells |
| Concentration: | 0, 25, 50, 100, and 200 μM |
| Incubation Time: | One hour before S100b addition for 4 hours |
| Result: | Dose-dependently inhibited mRNA expression of RAGE, MCP-1, COX-2, IP-10, and NOX2 stimulated with S100b. |
LR-90 (50 mg/L, p.o. for 27 weeks) significantly reduces plasma lipids, modestly affects hyperglycaemia in ZDF rats.
LR-90 (50 mg/L) decreases renal AGE, AGER and lipid peroxidation.
| Animal Model: | Male ZDF rats (13 to 40 weeks) |
| Dosage: | 50 mg/L |
| Administration: | P.O. for 27 weeks |
| Result: | Significantly reduced plasma triacylglycerol and cholesterol by ～55% and ～30%, respectively. Modestly affected hyperglycaemia and blood pressure. Lowered the body weight. |