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233254-24-5

中文名稱(chēng) 托美洛韋
英文名稱(chēng) TOMEGLOVIR
CAS 233254-24-5
分子式 C23H27N3O4S
分子量 441.54
MOL 文件 233254-24-5.mol
233254-24-5 結(jié)構(gòu)式 233254-24-5 結(jié)構(gòu)式

基本信息

中文別名
托美洛韋
英文別名
TOMEGLOVIR
BAY 38-4766
Tomeglovir (BAY-38-4766)
N-[4-[[[5-(Dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-(hydroxymethyl)-2-methylpropanamide
Propanamide, N-[4-[[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-(hydroxymethyl)-2-methyl-
所屬類(lèi)別
生物化工:激動(dòng)劑抑制劑

物理化學(xué)性質(zhì)

密度1.334±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : ≥ 108 mg/mL (244.60 mM)
酸度系數(shù)(pKa)8.96±0.50(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
托美洛韋價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱(chēng)CAS號(hào)包裝價(jià)格
2024/11/08HY-108261托美洛韋
Tomeglovir
233254-24-55mg1100元
2024/11/08HY-108261托美洛韋
Tomeglovir
233254-24-510mM * 1mLin DMSO1210元
2024/11/08HY-108261托美洛韋
Tomeglovir
233254-24-510mg1500元

常見(jiàn)問(wèn)題列表

生物活性
Tomeglovir 是一種抗 CMV 劑,能夠抑制病毒 DNA 多聯(lián)體的進(jìn)程,對(duì) HCMV 和 MCMV 的 IC50 值分別為 0.34 μM 和 0.039 μM。
靶點(diǎn)

IC50: 0.34 μM (HCMV), 0.039 μM (MCMV)

體外研究

Tomeglovir (BAY 38-4766) is a potent anti-CMV agent, with IC 50 s of 0.34 μM and 0.039 μM for HCMV and MCMV. Tomeglovir also suppresses HELF and NIH 3T3 cells, with CC 50 s of 85 μM and 62.5 μM, respectively. Tomeglovir (BAY 38-4766) inhibits HCMV Davis and various monkey CMV strains with EC 50 s of 1.03 ± 0.57 μM and < 1 μM.

體內(nèi)研究

Tomeglovir (BAY 38-4766; 3, 10, 30, 100 mg/kg, p.o.) dose-dependently reduces MCMV-DNA in salivary glands, livers and kidneys of MCMV-infected NOD-SCID mice, and prolongs the survival of the mice. Tomeglovir (10, 25 and 50 mg/kg) shows antiviral activity in the hollow fiber mouse model. Tomeglovir (BAY 38-4766) shows antiviral activity in SCID mice with MCMV, and the LD 50 is >2000 mg/kg in mice and rats.

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