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22033-87-0

中文名稱 奧利索西
英文名稱 Olesoxime
CAS 22033-87-0
分子式 C27H45NO
分子量 399.65
MOL 文件 22033-87-0.mol
更新日期 2024/11/15 18:20:32
22033-87-0 結(jié)構(gòu)式 22033-87-0 結(jié)構(gòu)式

基本信息

中文別名
奧利索西
膽甾-4-烯-3-酮肟
英文別名
(NE)-N-[10,13-dimethyl-17-(6-methylheptan-2-yl)-1,2,6,7,8,9,11,12,14,1 5,16,17-dodecahydrocyclopenta[a]phenanthren-3-ylidene]hydroxylamine
olesoxime
Cholest-4-en-3-one, oxime, NSC 21311
TRO 19622
Cholest-4-en-3-one oxime

物理化學(xué)性質(zhì)

熔點(diǎn)145-148 ºC
沸點(diǎn)510.0±23.0 °C(Predicted)
密度1.10
儲(chǔ)存條件−20°C
儲(chǔ)存條件-20°C
溶解度二甲基亞砜:>10mg/mL
酸度系數(shù)(pKa)12.27±0.70(Predicted)
形態(tài)固體
顏色白色
穩(wěn)定性Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
CAS 數(shù)據(jù)庫(kù)22033-87-0(CAS DataBase Reference)

安全數(shù)據(jù)

WGK Germany3
奧利索西價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2025/02/08HY-14796奧利索西
Olesoxime
22033-87-01 mg272元
2025/02/08HY-14796奧利索西
Olesoxime
22033-87-05mg680元
2025/02/08HY-14796奧利索西
Olesoxime
22033-87-010mM * 1mLin DMSO748元

常見(jiàn)問(wèn)題列表

生物活性
Olesoxime (TRO 19622) 是一種靶向線粒體的神經(jīng)保護(hù)性試劑,促進(jìn)細(xì)胞存活,EC50 為 3.2±0.2 μM。
靶點(diǎn)

Mitochondrial

體外研究

Exposure to Olesoxime (TRO 19622) (ranging from 0.1 to 10 μM) at 1 h after plating significantly protects primary embryonic rat spinal MNs (that had been cultured for 3 days without brain-derived, ciliary and glia-derived neurotrophic factors) from cell death. At a concentration of 10 μM, Olesoxime (TRO 19622) maintains survival of 74±10% of the neurons supported by a combination of neurotrophic factors (brain-derived, ciliary and glia-derived neurotrophic factors). The mean EC 50 in this assay is 3.2±0.2 μM. In addition to preserving MN cell bodies, Olesoxime (TRO 19622) also promotes the outgrowth of neurites. At a concentration of 1 μM, which increases cell survival by only 38%, Olesoxime (TRO 19622) increases overall neurite outgrowth per cell by 54%. Olesoxime (TRO 19622) belongs to a new family of cholesterol-oximes identified for its survival-promoting activity on purified motor neurons deprived of neurotrophic factors. Olesoxime (TRO 19622) targets proteins of the outer mitochondrial membrane, concentrates at the mitochondria and prevents permeability transition pore opening mediated by, among other things, oxidative stress.

體內(nèi)研究

Daily administration of Olesoxime (TRO 19622) (3 or 30 mg/kg sc) to adult mice for more than 2 months is well tolerated without toxicity or adverse effects. When animals are treated orally for 5 days following the lesion, Olesoxime (TRO 19622) increases motor neuron cell body survival in a dose-dependent manner with significant rescue at the highest dose of 100 mg/kg. At this dose, motor neuron survival is 29 ±2% (n=18) corresponding to a 42% increase in survival compared with vehicle-treated animals. Paclitaxel-treated rats that receive prophylactic treatment with 3 mg/kg/d or 30 mg/kg/d Olesoxime (TRO 19622) have 239±17.6 and 247±14.4 IENFs per cm, respectively. For both doses, the decreases are significantly less than the 46% decrease seen in the Paclitaxel-treated rats administered vehicle. However, both doses produce decreases (25% and 22%) that are significantly different relative to the na?ve control group.

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