210821-63-9
中文名稱
1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride
英文名稱
1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride
CAS
210821-63-9
分子式
C10H11ClF3N3.ClH
分子量
302.126
MOL 文件
210821-63-9.mol
210821-63-9 結(jié)構(gòu)式
基本信息
中文別名
化合物 T23110 英文別名
Org 12692Org12962HCl
Org 12962 hydrochloride
1-[6-Chloro-5-trifluoromethyl)-2-pyridinyl]-piperazinehydrochloride
1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride
物理化學(xué)性質(zhì)
儲存條件Sealed in dry,Room Temperature
溶解度Soluble to 50 mM in water and to 100 mM in DMSO
形態(tài)淡黃色固體。
常見問題列表
生物活性
Org 12962 hydrochloride 是一種有效的、選擇性的 5-HT2C 受體激動劑，對 5-HT2C，5-HT2A，5-HT2B 的 pEC50 分別為 7.01、6.38 和 6.28。Org 12962 hydrochloride 在焦慮大鼠的模型中顯示出緩解作用。靶點(diǎn)
|
5-HT 2C Receptor 7.01 (pEC 50 ) |
5-HT 2A Receptor 6.38 (pEC 50 ) |
5-HT 2B Receptor 6.28 (pEC 50 ) |
體內(nèi)研究
Org 12962 (intraperitoneal?injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg) displays antiaversive effects in a rat model of panic-like anxiety, it increases the postinjection frequency thresholds for self-interruption (F 3.71 =11.40). The dose of 0.3 mg/kg ip is not significantly active, that the dose of 1 mg/kg is marginally active and that 3.2 mg/kg ip induced highly significant antiaversive effects.
| Animal Model: | Male Wistar rats |
| Dosage: | 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg |
| Administration: | Intraperitoneal?injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg |
| Result: | Had a dose-related antipanic-like effect in SD-rat. |