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206996-13-6

中文名稱 BD1063(鹽酸鹽)
英文名稱 1-[2-(3,4-Dichlorophenyl)ethyl]-4-Methylpiperazine Dihydrochloride
CAS 206996-13-6
分子式 C13H20Cl4N2
分子量 346.123
MOL 文件 206996-13-6.mol
更新日期 2024/11/11 16:21:54
206996-13-6 結(jié)構(gòu)式 206996-13-6 結(jié)構(gòu)式

基本信息

中文別名
BD1063(鹽酸鹽)
英文別名
BD1063 HCl
BD 1063 (hydrochloride)
BD1063 (dhydrochloride)
BD-1063 DHYDROCHLORIDE
BD 1063 DHYDROCHLORIDE

物理化學(xué)性質(zhì)

儲(chǔ)存條件room temp
溶解度H2O:>15mg/mL
形態(tài)粉末
顏色白色至米色
水溶解性溶于水至100mM
穩(wěn)定性自購(gòu)買之日起 1 年內(nèi)保持穩(wěn)定。蒸餾水溶液可在 -20°C 下保存長(zhǎng)達(dá) 3 個(gè)月。

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H319
防范說明P305+P351+P338
危險(xiǎn)品標(biāo)志Xi
危險(xiǎn)類別碼36
安全說明26
WGK Germany3

應(yīng)用領(lǐng)域

用途1
The novel 蟽 receptor ligands eurotransmitter antagonists.
BD1063(鹽酸鹽)價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-18101ABD1063(鹽酸鹽)
BD1063 dhydrochloride
206996-13-65mg770元
2024/11/08HY-18101ABD1063(鹽酸鹽)
BD1063 dhydrochloride
206996-13-610mM * 1mLin Water847元
2024/11/08HY-18101ABD1063(鹽酸鹽)
BD1063 dhydrochloride
206996-13-610mg1100元

常見問題列表

生物活性
BD1063 2HCL (BD1063 dihydrochloride)是一種有效的選擇性 sigma-1 receptor (σ1R) 拮抗劑,對(duì)應(yīng)的Ki值為4.43 nM。
靶點(diǎn)
TargetValue
σ1R
(Cell-free assay)
4.43 nM(Ki)
體內(nèi)研究

BD1063 dose-dependently reduces ethanol self-administration in sP rats (3.3-11 mg/kg) and withdrawn, dependent Wistar rats (4-11 mg/kg) at doses that does not modify mean ethanol self-administration in non-dependent Wistar controls. BD1063 also reduces the breakpoints of sP rats to work for ethanol under a progressive-ratio reinforcement schedule. BD1063 dose-dependently reduces binge-like eating and the regularity of food responding, and blocks the increased eating rate in Palatable rats. In the light/dark conflict test, BD1063 antagonizes the increased time spent in the aversive compartment and the increased intake of the palatable diet, without affecting motor activity. The administration of BD1063 30 minutes before each paclitaxel dose prevents the development of cold and mechanical allodynia in WT mice. Moreover, the acute administration of BD1063 dose dependently reverses both types of paclitaxel-induced allodynia.

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