197250-15-0
中文名稱
GAP26
英文名稱
GAP 26
CAS
197250-15-0
分子式
C70H107N19O19S
分子量
1550.78
MOL 文件
197250-15-0.mol
更新日期
2024/11/03 16:22:42
197250-15-0 結(jié)構(gòu)式
基本信息
中文別名
VR-13化合物GAP 26
英文別名
GAP 26GAP-26
GAP26
43Gap 26, Connexin Mimetic
M.W. 1550.78 C70H107N19O19S
Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg
GAP 26/Connexin 43 (63-75) (human, bovine, mouse, rat), Gap Junction α-1 Protein (63-75)
L-Arginine, L-valyl-L-cysteinyl-L-tyrosyl-L-α-aspartyl-L-lysyl-L-seryl-L-phenylalanyl-L-prolyl-L-isoleucyl-L-seryl-L-histidyl-L-valyl-
所屬類別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
密度1.47±0.1 g/cm3(Predicted)
儲(chǔ)存條件Keep in dark place,Inert atmosphere,2-8°C
溶解度insoluble in EtOH; ≥155.1 mg/mL in H2O with ultrasonic; ≥77.55 mg/mL in DMSO with gentle warming and ultrasonic
酸度系數(shù)(pKa)3.31±0.10(Predicted)
形態(tài)固體
顏色White to off-white
水溶解性Soluble to 2 mg/ml in water
序列H-Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg-OH
GAP26價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/08/19 | HY-P1082 | GAP26 Gap 26 | 197250-15-0 | 1mg | 900元 |
| 2024/08/19 | HY-P1082 | GAP26 Gap 26 | 197250-15-0 | 5mg | 1800元 |
| 2024/08/19 | HY-P1082 | GAP26 Gap 26 | 197250-15-0 | 10mg | 2800元 |
常見(jiàn)問(wèn)題列表
生物活性
Gap 26 是一種連接蛋白模擬肽，由連接蛋白connexin 43 (Cx43)的細(xì)胞外環(huán)1的殘基 no. 63-75組成，是 gap junction 的抑制劑。Gap 26 可阻止光解inositol-1,4,5-trisphosphate觸發(fā)的ATP釋放。靶點(diǎn)
| Target | Value |
|
gap junction
() |
體外研究
Gap 26 (0.25 mg/mL, 30 min) reduces the wave size in the three cell lines (RBE4, SV-ARBEC and ECV304). Gap 26 (0.25 mg/mL, 30 min) completely abolishes the InsP3-triggered ATP response and reduced the ATP release to below the control level, indicating that the basal ATP release is also affected.
Gap 26 does indeed significantly inhibit our InsP3-triggered intercellular calcium waves, but it did not have any effect on dye coupling through junctional channels as evidenced by the FRAP experiments, despite the fact that connexin 43 was present in the cell lines used.
Gap 26 (100-300 μM) dose-dependently reduces the rhythmic responses of rabbit superior mesenteric arteries, with IC
50
of 28.4 ± 3.4 μM.