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188343-77-3

中文名稱 4-[2-(4-氟苯基)-5-(1-甲基-4-哌啶基)-1H-吡咯-3-基]吡啶
英文名稱 MBP146-78
CAS 188343-77-3
分子式 C21H22FN3
分子量 335.42
MOL 文件 188343-77-3.mol
更新日期 2024/12/03 15:40:35
188343-77-3 結(jié)構(gòu)式 188343-77-3 結(jié)構(gòu)式

基本信息

中文別名
4-[2-(4-氟苯基)-5-(1-甲基-4-哌啶基)-1H-吡咯-3-基]吡啶
英文別名
CS-2661
MBP146-78
MBP146-78
MBP146-78
4-[2-(4-Fluorophenyl)-5-(1-methyl-4-piperidinyl)-1H-pyrrol-3-yl]pyridine
Pyridine, 4-[2-(4-fluorophenyl)-5-(1-methyl-4-piperidinyl)-1H-pyrrol-3-yl]-

物理化學(xué)性質(zhì)

沸點(diǎn)477.6±45.0 °C(Predicted)
密度1.164±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : 7.69 mg/mL (22.93 mM)
酸度系數(shù)(pKa)16.04±0.50(Predicted)
形態(tài)Solid
顏色White to off-white
4-[2-(4-氟苯基)-5-(1-甲基-4-哌啶基)-1H-吡咯-3-基]吡啶價(jià)格(試劑級)
報(bào)價(jià)日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價(jià)格
2024/11/08HY-1015254-[2-(4-氟苯基)-5-(1-甲基-4-哌啶基)-1H-吡咯-3-基]吡啶
MBP146-78
188343-77-31mg450元
2024/11/08HY-1015254-[2-(4-氟苯基)-5-(1-甲基-4-哌啶基)-1H-吡咯-3-基]吡啶
MBP146-78
188343-77-35mg950元
2024/11/08HY-1015254-[2-(4-氟苯基)-5-(1-甲基-4-哌啶基)-1H-吡咯-3-基]吡啶
MBP146-78
188343-77-310mM * 1mLin DMSO1045元

常見問題列表

生物活性
MBP146-78 是一種有效的、選擇性的 cyclic GMP(cGMP)-dependent protein kinases/Protein Kinase G (PKG) 抑制劑,對弓形蟲Toxoplasma gondii表現(xiàn)出細(xì)胞抑制活性。
靶點(diǎn)
TargetValue
PKG
()
體外研究

MBP146-78 displays a dose-dependent inhibition of T. gondii tachyzoites replicating inside HFFs, with an IC 50 of 210 nM. The suppression of lytic parasite growth by MBP146-78 is reversible. Replacement of the medium with medium lacking MBP146-78, after treatment for up to 7 days at 2 μM, results in complete lysis of HFF cell monolayers. MBP146-78 is neither toxic nor inhibitory to proliferating or confluent monolayers of HFFs at concentrations of up to 10 μM.

體內(nèi)研究

In infected mice that are treated with MBP146-78 at 50 mg/kg twice daily, parasites are undetectable throughout the 10-day treatment period in each of the tissues examined. However, samples from brain, spleen, and lung taken from infected treated mice reveal the presence of parasites after cessation of administration of MBP146-78, indicating that a transient asymptomatic parasite recrudescence occurs in all survivors. The ability of mice to control Toxoplasma infection after MBP146-78 treatment has been terminated suggests that the mouse immune system plays a synergistic role with chemotherapy in controlling the infection.

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