18696-26-9
中文名稱
芥子堿
英文名稱
Sinapine
CAS
18696-26-9
分子式
[C16H24NO5]+.
MOL 文件
18696-26-9.mol
更新日期
2024/12/20 18:42:34
18696-26-9 結構式
基本信息
中文別名
芥子堿(標準品) 英文別名
SinapinSinapic acid choline ester
2-[[3-(4-Hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propenyl]oxy]-N,N,N-trimethylethanaminium
2-[[3-(4-Hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propen-1-yl]oxy]-N,N,N-trimethylethanaminium
Ethanaminium, 2-((3-(4-hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propenyl)o xy)-N,N,N-trimethyl-
Ethanaminium,2-[[3-(4-hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propen-1-yl]oxy]-N,N,N-trimethyl-
2-((3-(4-hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propenyl)o xy)-N,N,N-trimethyl-2-[[3-(4-Hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propenyl]oxy]-N,N,N-trimethylethanaminium
所屬類別
分析化學：中藥標準品物理化學性質
熔點178℃
儲存條件4°C, away from moisture and light
溶解度DMSO : 250 mg/mL (805.52 mM; Need ultrasonic)
形態(tài)粉末
顏色Off-white to yellow
LogP-3.370 (est)
常見問題列表
生物活性
Sinapine 是一種從十字花科物種的種子中分離出來的生物堿，具有抗氧化、抗腫瘤和放射防護的作用。Sinapine 通過下調 P-glycoprotein 來抑制Caco-2細胞的增殖。靶點
| Target | Value |
|
P-glycoprotein
() |
體外研究
Sinapine (6 or 60 μM; 1 h) counteracts H
2
O
2
and antimycin A-induced mitochondrial oxidative stress in cardiomyocytes.
Sinapine (10-200 μM; 24 h) inhibits the proliferation of Caco-2 cells in a dose-dependent manner, and has relatively low toxicity.
Sinapine (10-200 μM; 24 h) promotes doxorubicin accumulation in Caco-2 cell by inducing P-glycoprotein (P-gp) decrease.
Sinapine (10-200 μM; 24 h) significantly reduces phosphorylation of FRS2α, ERK1/2.
體內研究
Sinapine reduces non-alcoholic fatty liver disease in mice by modulating the composition of the gut microbiota.