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18422-05-4

中文名稱 腺苷-5'-單磷酸一水合物
英文名稱 Adenosine 5'-monophosphate monohydrate
CAS 18422-05-4
EINECS 編號 200-500-0
分子式 C10H16N5O8P
MDL 編號 MFCD00149360
分子量 365.24
MOL 文件 18422-05-4.mol
更新日期 2024/10/28 21:59:58
18422-05-4 結構式 18422-05-4 結構式

基本信息

中文別名
腺苷-5-磷酸
腺苷-5'-磷酸
腺苷-5'-單磷酸一水合物
腺苷-5'-磷酸(一水)
英文別名
5'-ADENYLIC ACID
5-ADENYLIC ACID
5'-AMP H2O
5'-AMP MONOHYDRATE
A-5'-P
ADENOSINE 5'-MONOPHOSPHATE
ADENOSINE 5'-MONOPHOSPHATE MONOHYDRATE
ADENOSINE 5'-MONOPHOSPHORIC ACID MONOHYDRATE
ADENYLIC ACID MONOHYDRATE
AMP
ADENOSINE 5'-MONOPHOSPHATE FREE ACID97+% FROM YEAS
5'-AMP=Adenylicacid
ADENOSINE-5'-MONOPHOSPHATE 1-HYDRATE
5-Adenylic acid, monohydrate
Adenosine-5''-monophosphoric acid (and/or unspecified salts)
5'-AMP
Adenosine-5'-monophosphoric acid monohydrate >96%
AMP monohydrate
5μ-AMP, Adenylic acid from muscle, AMP
5μ-Adenylic acid, 5μ-AMP, A-5μ-P, AMP
所屬類別
生物化工:激動劑抑制劑

物理化學性質

熔點183-188 °C (dec.)(lit.)
比旋光度-48 º (c=2% in 2% NaOH)
儲存條件2-8°C
溶解度H2O: with addition of mild alkalisoluble
形態(tài)固體
顏色白色至灰白色
Merck14,158
BRN5205540

安全數據

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H302-H315-H319-H335
危險品標志Xi
危險類別碼36/37/38
安全說明26-36
WGK Germany3
RTECS號AU7480500
TSCAYes
海關編碼2934999090

應用領域

用途1
生化研究。

常見問題列表

簡介
腺苷-5'-單磷酸一水合物為核苷酸類衍生物,可用作生化試劑。
生物活性
Adenosine 5'-monophosphate monohydrate 是一個腺苷 A1 受體 (adenosine A1 receptor) 激動劑。Adenosine 5'-monophosphate monohydrate 對 HSV-1 和 HSV-2 具有顯著的抗病毒活性。
靶點

Adenosine A 1 receptor

體外研究

Adenosine 5'-monophosphate monohydrate is an adenosine A1 receptor agonist. Adenosine 5'-monophosphate monohydrate (5′-AMP)-induced cell toxicity is negligible at concentrations of 25 to 400?μM in RAW264.7 cells. Adenosine 5'-monophosphate monohydrate significantly attenuates the mRNA expression of tumor necrosis factor-α (TNF-α) and interleukin (IL)-6 in RAW264.7 cells. The dose-dependence of TNF-α and IL-6 mRNA show that at concentration of 400?μM, Adenosine 5'-monophosphate monohydrate exhibits the maximum inhibition. Exposure of cells to Adenosine 5'-monophosphate monohydrate significantly reduces recruitment of NF-κB p65 to TNF-α, IL-6, and IL-1β gene promoters.

體內研究

C57BL/6J mice treated with Adenosine 5'-monophosphate monohydrate (5′-AMP) markedly increases hepatic adenosine level. Survival rate in PBS-treated mice (n=15) is 60% (8?h) and 33.3% (24?h), whereas survival rate in Adenosine 5'-monophosphate monohydrate-treated mice (n=15) is 100% (8?h) and 93.3% (24?h). Serum aspartate transaminase (AST) and alanine transaminase (ALT) levels are significantly lowered in the Adenosine 5'-monophosphate monohydrate group than in the vehicle group. The area and extent of necrosis is attenuated and the infiltration of inflammatory cells is reduced in the Adenosine 5'-monophosphate monohydrate group.

知名試劑公司產品信息

腺苷-5'-單磷酸一水合物價格(試劑級)
報價日期產品編號產品名稱CAS號包裝價格
2024/08/19HY-A0181A腺苷-5'-單磷酸一水合物
Adenosine 5'-monophosphate monohydrate
18422-05-4500mg400元
2024/08/19HY-A0181A腺苷-5'-單磷酸一水合物
Adenosine 5'-monophosphate monohydrate
18422-05-410mM * 1mLin Water500元
2024/08/19HY-A0181A腺苷-5'-單磷酸一水合物
Adenosine 5'-monophosphate monohydrate
18422-05-41g500元
"18422-05-4" 相關產品信息
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