1841-19-6
1841-19-6 結構式
基本信息
中文別名
氟蟲靈氟斯必靈
氟司必林
帕羅西汀 雜質C
帕羅西汀EP雜質C
氟司必林 EP標準品
英文別名
imapR 6218
Redeptin
mcn-jr-6218
Fluspirilen
FLUSPIRILENE
Fluspirilene CRS
Fluspirilene (R 6218
FLUSPIRILENE USP/EP/BP
Paroxetine EP IMpurity C
所屬類別
原料藥：抗精神病藥物理化學性質
熔點187.5-190°
沸點668.9±55.0 °C(Predicted)
密度1.1634 (estimate)
儲存條件room temp
溶解度DMSO: soluble
酸度系數(pKa)15.05±0.20(Predicted)
形態(tài)amorphous solid
顏色white to yellow
CAS 數據庫1841-19-6
安全數據
警示詞危險
危險性描述H410-H301
危險品運輸編號3249
WGK Germany3
RTECS號XX8750000
危險等級6.1(b)
包裝類別III
毒性LD50 i.m. in rats: 146 ±14 mg/kg (Janssen)
常見問題列表
生物活性
Fluspirilene是L型鈣通道的非競爭性拮抗劑，IC50為0.03 μM。Fluspirileneis是一種用于精神分裂癥的長效可注射抗精神病藥物。靶點
IC50: 0.03 μM (L-type calcium channel)
體外研究
Fluspirilene, at concentrations which non-competitively modify dihydropyridine binding, selectively antagonizes the effects of calcium-channel activators. Fluspirilene decreases the viability and suppresses sphere-forming of glioma stem cell lines in a dose-dependent manner. Fluspirilene demonstrates the inhibition of proliferation of T98, U87 and all GSC lines at 1.25, 2.5, and 5 μM, while it inhibits the proliferation of U251 and SNB19 at 2.5 and 5 μM.
體內研究
Mice treated with fluspirilene shows a remarkable reduction of the tumor size. Fluspirilene significantly prolongs survival of the TGS04 mouse model.