179248-59-0
中文名稱
7-二甲氧基-N-(4-苯氧基苯基)- 氨基喹唑啉
英文名稱
6,7-Dimethoxy-N-(4-phenoxyphenyl)-
CAS
179248-59-0
分子式
C22H19N3O3
分子量
373.4
MOL 文件
179248-59-0.mol
更新日期
2025/01/02 20:22:47
179248-59-0 結(jié)構式
基本信息
中文別名
SRC抑制劑1化合物SRC INHIBITOR 1
7-二甲氧基-N-(4-苯氧基苯基)- 氨基喹唑啉
6,7-二甲氧基-N-(4-苯氧基苯基)-4-喹唑啉胺
雙位點SRC酪氨酸激酶抑制劑(SRC INHIBITOR 1)
英文別名
EdrHHAT
HB-1
Mar2
MART2
SKI-1
MEF3L
Src I1
Src-l1
Src Inhibitor-1
所屬類別
生物化工：酪氨酸類衍生物物理化學性質(zhì)
儲存條件2-8°C
溶解度二甲基亞砜：>10mg/mL
形態(tài)白色粉末
顏色白色或灰白色
穩(wěn)定性Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.
7-二甲氧基-N-(4-苯氧基苯基)- 氨基喹唑啉價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-101053 | 7-二甲氧基-N-(4-苯氧基苯基)- 氨基喹唑啉 Src Inhibitor 1 | 179248-59-0 | 2mg | 500元 |
| 2024/11/08 | HY-101053 | 7-二甲氧基-N-(4-苯氧基苯基)- 氨基喹唑啉 Src Inhibitor 1 | 179248-59-0 | 10mM * 1mLin DMSO | 575元 |
| 2024/11/08 | HY-101053 | 7-二甲氧基-N-(4-苯氧基苯基)- 氨基喹唑啉 Src Inhibitor 1 | 179248-59-0 | 5mg | 700元 |
常見問題列表
生物活性
Src Inhibitor 1是Src和Lck的競爭性抑制劑，IC50分別為44 nM和88 nM。它也能抑制Csk和Yes。靶點
| Target | Value |
|
Src
(Cell-free assay) | 44 nM |
|
Lck
(Cell-free assay) | 88 nM |
體外研究
Src-I1 is competitive with both ATP and peptide binding sites of the kinase. The IC 50 values are 44 and 88 nM for Src and Lck, respectively. Src-I1, is found to be a potent inhibitor of Src (IC 50 =0.18 μM), but also inhibited other Src family members, such as Lck, Csk and Yes with similar potency to Src, and RIP2 (IC 50 =0.026 μM) with even greater potency. In addition, it inhibited CHK2 with similar potency to Src, and Aurora B with slightly lower potency.