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1758-80-1

中文名稱(chēng) L-2,4-二氨基丁酸氫溴酸鹽
英文名稱(chēng) L-DAB HBR
CAS 1758-80-1
分子式 C4H11BrN2O2
MDL 編號(hào) MFCD07368664
分子量 199.05
MOL 文件 1758-80-1.mol
更新日期 2024/08/05 10:18:06
1758-80-1 結(jié)構(gòu)式 1758-80-1 結(jié)構(gòu)式

基本信息

中文別名
L-2,4-二氨基丁酸氫溴酸鹽
英文別名
L-2,4-DIAMINOBUTYRIC ACID HYDROBROMIDE
L-DAB HBR
L-DAB HYDROBROMIDE
L-Dab•
L-2,4-Diaminobutanoate
H-DabHBr
(S)-2,4-Diaminobutyric acid
L-DABA
所屬類(lèi)別
生物化工:氨基酸鹽

物理化學(xué)性質(zhì)

熔點(diǎn)216-218 °C
沸點(diǎn)321.0±32.0 °C(Predicted)
密度1.218±0.06 g/cm3(Predicted)
儲(chǔ)存條件2-8°C(protect from light)
酸度系數(shù)(pKa)2.00±0.10(Predicted)
形態(tài)Powder
顏色White to off-white
CAS 數(shù)據(jù)庫(kù)1758-80-1(CAS DataBase Reference)

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335
防范說(shuō)明P261-P305+P351+P338
海關(guān)編碼2922498590
L-2,4-二氨基丁酸氫溴酸鹽價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱(chēng)CAS號(hào)包裝價(jià)格
2024/11/08HY-101414L-2,4-二氨基丁酸氫溴酸鹽
L-DABA
1758-80-1100mg500元

常見(jiàn)問(wèn)題列表

生物活性
L-DABA (L-2,4-Diaminobutyric acid)是GABA轉(zhuǎn)氨酶的弱抑制劑,IC50 值大于500 μM。在體內(nèi)和體外具有抗腫瘤活性。
靶點(diǎn)

Human Endogenous Metabolite

體外研究

The tumor cells are irreversibly and totally damaged by incubation with 10 mM L-2,4-Diaminobutyric acid for 24 h at 37°C. The cell-destructive effect by L-DABA is probably due to an osmotic lysis induced by the non-saturated intracellular accumulation of L-DABA. The harmful effect of L-DABA could be abolished by concomitant incubation with L-alanine and L-methionine. Kinetic studies indicates that L-DABA is a non-linear, non-competitive inhibitor of GABA transaminase activity. The L-DABA-induced elevation of GABA levels parallels the inhibition of GABA transaminase activity. L-2,4-Diaminobutyric acid, an amino acid analogue, produceS a cytolytic effect with a human glioma cell line, SKMG-1, and normal human fibroblasts. The concentrations of L-DABA necessary to reduce the cell count to 50% of control following a 24-h incubation at 37°C are 12.5 mM for the human fibroblasts and 20 mM for the glioma cell line.

體內(nèi)研究

Treatment with L-DABA results in 43.4% reduction of tumor growth. L-DABA is a more effective inhibitor of GABA transaminase in vivo than in vitro .

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