172377-52-5
中文名稱
172377-52-5
英文名稱
Motolimod
CAS
172377-52-5
分子式
C18H25NO4S
分子量
351.46
MOL 文件
172377-52-5.mol
更新日期
2023/03/20 15:41:25
172377-52-5 結(jié)構(gòu)式
基本信息
中文別名
雌二醇 3-氨基磺酸 英文別名
E2MATEES-J 995
BLE 00084
Estradiol 3-sulfamate
Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-sulfamate
物理化學(xué)性質(zhì)
熔點(diǎn)202-204 °C(Solv: methanol (67-56-1))
沸點(diǎn)531.1±60.0 °C(Predicted)
密度1.319±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO: 62.5 mg/mL (177.83 mM)
酸度系數(shù)(pKa)8.88±0.70(Predicted)
形態(tài)Solid
顏色White to off-white
172377-52-5價(jià)格(試劑級)
| 報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
| 2024/08/19 | HY-U00112 | 172377-52-5 Estradiol 3-sulfamate | 172377-52-5 | 1mg | 1800元 |
| 2024/08/19 | HY-U00112 | 172377-52-5 Estradiol 3-sulfamate | 172377-52-5 | 5mg | 3600元 |
| 2024/08/19 | HY-U00112 | 172377-52-5 Estradiol 3-sulfamate | 172377-52-5 | 10mM * 1mLin DMSO | 3960元 |
常見問題列表
生物活性
Estradiol 3-sulfamate (BLE 00084; E2MATE; ES-J 995) 是一種長效和有口服活性的類固醇硫酸酯酶 (steroid sulfatase) 抑制劑；抑制雌酮硫酸酯酶的 IC50 值為251 nM，Ki 值為133 nM。靶點(diǎn)
IC50: 251 nM (estrone sulfatase)
Ki: 133 nM (estrone sulfatase)
體外研究
Introduction of a fluoro, chloro, or bromo moiety at the C-2 position of EMATE and Estradiol 3-sulfamate and that of a fluoro moiety at the C-4 position of the parent sulfamates markedly increase the estrone sulfatase inhibitory activity.
體內(nèi)研究
Estradiol 3-sulfamate is readily transformed and absorbed in the gut into its oxidative metabolite, EMATE, and both compounds have already been shown to be potent, long-acting, and orally active STS inhibitors.