1553-56-6
中文名稱
-膽烷酸
英文名稱
3-Oxo-5beta-cholanoic Acid
CAS
1553-56-6
分子式
C24H38O3
分子量
374.56
MOL 文件
1553-56-6.mol
更新日期
2024/10/29 11:24:19
1553-56-6 結(jié)構(gòu)式
基本信息
中文別名
-膽烷酸脫氫石膽酸
3-氧代-5&Β
3-酮-5B-膽烷酸
化合物 T13502
3-氧代-5Β-膽酸
3-氧代-5Β-膽烷酸
3-氧代-5&BETA
3-惡唑烷-24-油酸
3-氧代-5BETA-膽酸
英文別名
3-oxocholanicacid3-KETOCHOLANIC ACID
3-oxolithocholicacid
3-ketolithocholicacid
3-Oxo-5β-cholanic acid
5β-CHOLANIC acid-3-ONE
5-B-CHOLANIC ACID-3-ONE
DEHYDROLITHOCHOLIC ACID
3-oxocholan-24-oic acid
5β-Cholanic acid-3-one
物理化學(xué)性質(zhì)
熔點(diǎn)140-141 °C
沸點(diǎn)509.3±23.0 °C(Predicted)
密度1.069±0.06 g/cm3(Predicted)
儲存條件Refrigerator
溶解度可溶于氯仿（少許）、甲醇（少許）
酸度系數(shù)(pKa)4.76±0.10(Predicted)
形態(tài)固體
顏色白色至淡黃色
CAS 數(shù)據(jù)庫1553-56-6
常見問題列表
生物活性
3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid)，膽汁酸代謝產(chǎn)物，通過直接與關(guān)鍵轉(zhuǎn)錄因子RORγt (Kd=1.13 μM) 結(jié)合抑制 TH17 細(xì)胞分化。體外研究
Treatment with 3-Oxo-5β-cholanoic acid significantly reduced the activity of the RORγt reporter. These data suggest that 3-Oxo-5β-cholanoic acid probably inhibits TH17 cell differentiation by physically interacting with RORγt, and inhibiting its transcriptional activity.
體內(nèi)研究
3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (0.3% (w/w); p.o.; for 1 week) significantly reduces the percentage of ileal TH17 cells.
| Animal Model: | B6 Jax mice (with a faecal slurry containing SFB) |
| Dosage: | 0.3% (w/w) |
| Administration: | Gavaged; for 1 week |
| Result: | Significantly reduced the percentage of ileal TH17 cells. |