153437-55-9
中文名稱(chēng)
153437-55-9
英文名稱(chēng)
4-(3'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE, HCL
CAS
153437-55-9
分子式
C16H16ClN3O3
分子量
333.77
MOL 文件
153437-55-9.mol
153437-55-9 結(jié)構(gòu)式
基本信息
中文別名
WHI-P180鹽酸鹽 英文別名
WHI-P180 HClJanex 3 hydrochloride
WHI-P180, HYDROCHLORIDE
4-(3'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE, HCL
所屬類(lèi)別
生物化工：激動(dòng)劑抑制劑常見(jiàn)問(wèn)題列表
生物活性
WHI-P180 (Janex 3)是多種激酶抑制劑；抑制 RET，KDR 和 EGFR 的IC50 值分別為5 nM，66 nM 和4 μM。靶點(diǎn)
|
EGFR 4 μM (IC 50 ) |
KDR 66 nM (IC 50 ) |
RET 5 nM (IC 50 ) |
體內(nèi)研究
WHI-P180 is also an active inhibitor of IgE-mediated mast cell responses. The elimination half-life of WHI-P180 in CD-1 mice (BALB/c mice) following i.v., i.p., or p.o. administration is less than 10 min. Systemic clearance of WHI-P180 is 6742 mL/h/kg in CD-I mice and 8188 mL/h/kg in BALB/c mice. Notably, WHI-P180, when administered in two consecutive nontoxic i.p. bolus doses of 25 mg/kg, inhibits IgE/antigen-induced vascular hyperpermeability in a well-characterized murine model of passive cutaneous anaphylaxis.