153088-73-4
中文名稱
CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE
英文名稱
Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE
CAS
153088-73-4
分子式
C20H17Cl2NO7
分子量
454.26
MOL 文件
153088-73-4.mol
更新日期
2025/01/07 10:41:56
153088-73-4 結(jié)構(gòu)式
基本信息
中文別名
半胱天冬酶-1 抑制劑 VPASE-1 INHIBITOR V
英文別名
Z-D-CH2-DCBZ-ASP-CH2-DCB
ICE INHIBITOR V
ICE INHIBITOR VI
CASPASE-1 INHIBITOR V
CASPASE-1 INHIBITOR III
Z-ASP-[(2,6-DICHLOROBENZOYL)OXY]METHANE
Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE
N-CBZ-L-ASPARTIC ACID A-(2 6-DICHLORO- &
Z-L-ASP-ALPHA-[(2,6-DICHLOROBENZOYL)OXY]METHANE
物理化學(xué)性質(zhì)
儲存條件−20°C
溶解度溶于 DMSO（高達(dá) 25 mg/ml）。
形態(tài)白色至類白色粉末。
顏色白色
穩(wěn)定性自購買之日起 1 年內(nèi)保持穩(wěn)定。 DMSO 中的溶液可在 -20° 下保存長達(dá) 3 個月。
CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE價(jià)格(試劑級)
| 報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-113953 | CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE Z-Asp-CH2-DCB | 153088-73-4 | 1mg | 500元 |
| 2024/11/08 | HY-113953 | CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE Z-Asp-CH2-DCB | 153088-73-4 | 5mg | 800元 |
| 2024/11/08 | HY-113953 | CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE Z-Asp-CH2-DCB | 153088-73-4 | 10 mM * 1 mLin DMSO | 880元 |
常見問題列表
生物活性
Z-Asp-CH2-DCB 是一種不可逆的廣譜 caspase 抑制劑，Z-Asp-CH2-DCB 也能抑制具有 caspase 樣活性的蛋白酶。Z-D-CH2-DCB 并以劑量依賴的方式阻斷 PBMC 細(xì)胞中的金黃色葡萄球菌腸毒素 B (SEB) 刺激的 IL-1β、TNF-α、IL-6 和 IFN-γ 的產(chǎn)生，和降低 SEB-1 刺激的 T 細(xì)胞增殖。Z-Asp-CH2-DCB 可預(yù)防 SU5416 誘導(dǎo)的間隔細(xì)胞凋亡和肺氣腫的發(fā)生。體外研究
Z-Asp-CH2-DCB (10-100 μM) blocks the production of IL-1β, TNF-α, IL-6, and IFN-γ in SEB-stimulated (200 ng; 16 hours) PBMC in a dose-dependent manner. The production of the chemokines MCP-1, MIP-1α, and MIP-1β was also suppresses. The inhibitory effect of Z-Asp-CH2-DCB on TSST-1-activated PBMC is similar, reducing IL-1β, IL-6, TNF-α, IFN-γ, MCP-1, MIP-1α, and MIP-1β to 10, 36, 25, 10, 11, 25, and 30%, respectively, of levels in untreated cells.
Z-Asp-CH2-DCB (10-100 μM; 48 hours) inhibits T-cell proliferation in PBMC stimulated with 200 ng of SEB/ml .
Cell Viability Assay
| Cell Line: | Human peripheral blood mononuclear cells |
| Concentration: | 10, 50, 100 μM |
| Incubation Time: | 48 hours |
| Result: | Inhibited T-cell proliferation in PBMC stimulated with SEB. |
體內(nèi)研究
Z-Asp-CH2-DCB (1 mg; i.p.; every day for 3 weeks) prevents SU5416-induced septal cell apoptosis.
| Animal Model: | Male Sprague-Dawley rats (SU5416+ Z-Asp-CH2-DCB group) |
| Dosage: | 1 mg |
| Administration: | Intraperitoneal injection; every day for 3 weeks |
| Result: | The caspase 3-like activity in SU5416-treated rat lungs is significantly higher, whereas lungs from rats treated with SU5416+Z-Asp-CH2-DCB showed no increase in apoptotic activity. |