152885-49-9
中文名稱
化合物 T27772
英文名稱
Urea, N-[(3R)-5-cyclohexyl-2,3-dihydro-1-methyl-2-oxo-1H-1,4-benzodiazepin-3-yl]-N'-[3-(methyl-1H-tetrazol-5-ylamino)phenyl]- (9CI)
CAS
152885-49-9
分子式
C25H29N9O2
分子量
487.56
MOL 文件
152885-49-9.mol
152885-49-9 結(jié)構(gòu)式
基本信息
中文別名
化合物 T27772 英文別名
L736L 736
L-736
L736380
L-736380
L 736380
Urea, N-[(3R)-5-cyclohexyl-2,3-dihydro-1-methyl-2-oxo-1H-1,4-benzodiazepin-3-yl]-N'-[3-(methyl-1H-tetrazol-5-ylamino)phenyl]- (9CI)
應(yīng)用領(lǐng)域
用途一
L-736380, also known as L-736,380, is a CCK-B receptor antagonist. L-736,380 dose-dependently inhibited gastric acid secretion in anesthetized rats (ID(50), 0.064 mg/kg) and ex vivo binding of [(125)I]CCK-8S in BKTO mice brain membranes (ED(50), 1.7 mg/kg) and is one of the most potent acidic CCK-B receptor antagonists yet described.