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1380228-30-7

中文名稱 3-Furansulfonamide, N-[2,4-difluoro-3-[[3-(9H-purin-6-yl)-2-pyridinyl]amino]phenyl]-
英文名稱 3-Furansulfonamide, N-[2,4-difluoro-3-[[3-(9H-purin-6-yl)-2-pyridinyl]amino]phenyl]-
CAS 1380228-30-7
分子式 C20H13F2N7O3S
分子量 469.42
MOL 文件 1380228-30-7.mol
1380228-30-7 結(jié)構(gòu)式 1380228-30-7 結(jié)構(gòu)式

基本信息

中文別名
化合物 T27614
英文別名
INU152
INU-152
INU 152
3-Furansulfonamide, N-[2,4-difluoro-3-[[3-(9H-purin-6-yl)-2-pyridinyl]amino]phenyl]-

應(yīng)用領(lǐng)域

用途一
INU-152 is a novel pan-RAF inhibitor with potent anti-tumor activity in preclinical models of BRAFV600E mutant cancer. INU-152 inhibits all RAF isoforms and inhibits MAPK pathways in mutant BRAF cells. More importantly, INU-152 exhibits minimal paradoxical pathway activation in melanoma cells with mutant RAS. INU-152 exhibits anti-tumor activities in xenograft models carrying BRAF mutations
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