| Identification | Back Directory | [Name]
3-Furansulfonamide, N-[2,4-difluoro-3-[[3-(9H-purin-6-yl)-2-pyridinyl]amino]phenyl]- | [CAS]
1380228-30-7 | [Synonyms]
INU152
INU-152
INU 152
3-Furansulfonamide, N-[2,4-difluoro-3-[[3-(9H-purin-6-yl)-2-pyridinyl]amino]phenyl]- | [Molecular Formula]
C20H13F2N7O3S | [MDL Number]
MFCD28502127 | [MOL File]
1380228-30-7.mol | [Molecular Weight]
469.42 |
| Hazard Information | Back Directory | [Description]
INU-152 is a novel pan-RAF inhibitor with potent anti-tumor activity in preclinical models of BRAFV600E mutant cancer. INU-152 inhibits all RAF isoforms and inhibits MAPK pathways in mutant BRAF cells. More importantly, INU-152 exhibits minimal paradoxical pathway activation in melanoma cells with mutant RAS. INU-152 exhibits anti-tumor activities in xenograft models carrying BRAF mutations |
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