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13558-31-1

中文名稱(chēng) 羅丹明
英文名稱(chēng) RHODAMINE 110
CAS 13558-31-1
EINECS 編號(hào) 236-944-7
分子式 C20H15ClN2O3
MDL 編號(hào) MFCD00042009
分子量 366.8
MOL 文件 13558-31-1.mol
更新日期 2024/10/23 10:56:49
13558-31-1 結(jié)構(gòu)式 13558-31-1 結(jié)構(gòu)式

基本信息

中文別名
羅丹明
羅丹明560
氯化羅丹明 110
羅明丹110
英文別名
O-(6-AMINO-3-IMINO-3H-XANTHEN-9-YL)BENZOIC ACID HYDROCHLORIDE
R110
RHODAMIN 110 CHLORIDE
RHODAMINE 110
RHODAMINE 110 CHLORIDE
RHODAMINE 560
RHODAMINE HYDROCHLORIDE
3,6-diamino-9-(2-carboxyphenyl)xanthylium chloride
RHODAMINE 110 CHLORIDE, FOR FLUOR-ESCENC E
Rhodamine 110, laser grade, pure, 99%
2-(6-Amino-3-imino-3H-xanthen-9-yl)-benzoic acid hydrochloride
Exciton Rhodamine 560 Chloride
Rhodamin 110
Rhodamine 110, 99%, laser grade, pure
3,6-Diamino-9-(2-carboxyphenyl)xanthylium
所屬類(lèi)別
染料及顏料:堿性染料

物理化學(xué)性質(zhì)

熔點(diǎn)>300 °C(lit.)
密度1.2504 (rough estimate)
折射率1.6470 (estimate)
儲(chǔ)存條件Keep in dark place,Inert atmosphere,Room temperature
溶解度可溶于乙醇
形態(tài)結(jié)晶粉末
顏色白色至淺黃色
最大波長(zhǎng)(λmax)499nm (MeOH); 496nm (H2O)
BRN4631860
穩(wěn)定性有吸濕性、光敏性
生物領(lǐng)域應(yīng)用Detecting risk of Alzheimer’s disease and stroke;evaluating/testing sperm quality; identifying bacteria; as a substrate for measuring aromatase activity, azoreductase activity,phospholipase activity, proteases activity (caspase activity, cathepsin C activity, elastase activity proteinase activity);implantable drug-delivery devices
主要應(yīng)用Color filters; liquid crystal displays; dye lasers;electroluminescent displays;inks;light-emitting diode (LED);papermaking process; recording materials; solar cells; silica thin films;sol–gel titania films;waveguides
CAS 數(shù)據(jù)庫(kù)13558-31-1(CAS DataBase Reference)

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302
防范說(shuō)明P301+P312
危險(xiǎn)品標(biāo)志Xn
危險(xiǎn)類(lèi)別碼22
安全說(shuō)明22-24/25
WGK Germany3
海關(guān)編碼29329990

應(yīng)用領(lǐng)域

用途1
激光染料。

常見(jiàn)問(wèn)題列表

吸收及優(yōu)點(diǎn)
羅丹明類(lèi)探針的優(yōu)點(diǎn)是內(nèi)酰胺環(huán)打破了氧雜蒽的π共軛,導(dǎo)致極低的吸收和熒光背景;在分析物的作用下,開(kāi)環(huán)后可以恢復(fù)羅丹明的顏色和熒光,實(shí)現(xiàn)高信號(hào)/背景比分析。但是衍生物開(kāi)環(huán)后通常在500 ~ 550 nm處出現(xiàn)最大吸收峰,在520 ~ 580 nm處發(fā)出熒光,這對(duì)于生物成像來(lái)說(shuō)波長(zhǎng)相對(duì)較短。
生物活性
Rhodamine 110 是一種靈敏和選擇性的底物 (substrate),用于測(cè)定溶液或活細(xì)胞內(nèi)的蛋白酶。激發(fā)波長(zhǎng)為 498 nm,發(fā)射波長(zhǎng)為 521 nm。
體外研究

Rhodamine 110 accumulates in mitochondria in a cationic form, which alters the pH in this cellular compartment. Rhodamine 110 accumulates in human lymphoblastoid cells and Friend leukemia cells. No cytotoxicity to human lymphoblastoid cells is observed below 10 μM, but Rhodamine 110 causes Friend leukemia cells to die at a concentrations above 100 μM.

體內(nèi)研究

Rhodamine 110 is less toxic than the parent molecule based on the intravenous LD 50 acute toxicity values of 89.5 mg/kg and 140.0 mg/kg for Rhodamine B and Rhodamine 110, respectively. Both molecules induce liver and kidney enlargement after ingestion, and male rats show more significant increases than female rats after Rhodamine 110 exposure. In addition, testis weight increased in male rats dosed with Rhodamine 110. The pharmacokinetics of Rhodamine 110 are assessed following oral administration at two dosages (3 and 10 mg/kg) and intravenous administration at one dosage (3 mg/kg). Pharmacokinetic parameters are calculated using an extravascular input and IV-bolus input, noncompartmental model analysis conducted with WinNonlin Standard Edition. The pharmacokinetic parameters of Rhodamine 110 indicates that the maximum plasma concentrations (C max ) of the two oral dosages are 283.4 and 657.0 ng/mL, which are reached at 140 and 210 min, respectively. This indicates that Rhodamine 110 absorption is not rapid after ingestion, as it took over 2 h to be absorbed from the intestines into the blood. The areas under the concentration–time curves (AUCs) for the two dosages are 138.1±20.3 and 444.0±170.8 h ng/mL. The pharmacokinetic data demonstrate that the AUC is proportional to the administered oral dose of Rhodamine 110 (3 mg/kg and 10 mg/kg). Furthermore, the clearance (Cl) of the two orally administered doses is 7.94 and 8.61 mL/min/kg, respectively.

羅丹明價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱(chēng)CAS號(hào)包裝價(jià)格
2024/08/1941907羅丹明110(99%)
Rhodamine 110, 98+%, pure, laser grade
13558-31-1500mg2707元
2024/08/1941907羅丹明110(99%)
Rhodamine 110, 98+%, pure, laser grade
13558-31-12.5g8333元
2024/08/19HY-D0817羅丹明
Rhodamine 110
13558-31-150mg500元
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