13558-31-1
基本信息
羅丹明560
氯化羅丹明 110
羅明丹110
R110
RHODAMIN 110 CHLORIDE
RHODAMINE 110
RHODAMINE 110 CHLORIDE
RHODAMINE 560
RHODAMINE HYDROCHLORIDE
3,6-diamino-9-(2-carboxyphenyl)xanthylium chloride
RHODAMINE 110 CHLORIDE, FOR FLUOR-ESCENC E
Rhodamine 110, laser grade, pure, 99%
2-(6-Amino-3-imino-3H-xanthen-9-yl)-benzoic acid hydrochloride
Exciton Rhodamine 560 Chloride
Rhodamin 110
Rhodamine 110, 99%, laser grade, pure
3,6-Diamino-9-(2-carboxyphenyl)xanthylium
物理化學(xué)性質(zhì)
常見(jiàn)問(wèn)題列表
Rhodamine 110 accumulates in mitochondria in a cationic form, which alters the pH in this cellular compartment. Rhodamine 110 accumulates in human lymphoblastoid cells and Friend leukemia cells. No cytotoxicity to human lymphoblastoid cells is observed below 10 μM, but Rhodamine 110 causes Friend leukemia cells to die at a concentrations above 100 μM.
Rhodamine 110 is less toxic than the parent molecule based on the intravenous LD 50 acute toxicity values of 89.5 mg/kg and 140.0 mg/kg for Rhodamine B and Rhodamine 110, respectively. Both molecules induce liver and kidney enlargement after ingestion, and male rats show more significant increases than female rats after Rhodamine 110 exposure. In addition, testis weight increased in male rats dosed with Rhodamine 110. The pharmacokinetics of Rhodamine 110 are assessed following oral administration at two dosages (3 and 10 mg/kg) and intravenous administration at one dosage (3 mg/kg). Pharmacokinetic parameters are calculated using an extravascular input and IV-bolus input, noncompartmental model analysis conducted with WinNonlin Standard Edition. The pharmacokinetic parameters of Rhodamine 110 indicates that the maximum plasma concentrations (C max ) of the two oral dosages are 283.4 and 657.0 ng/mL, which are reached at 140 and 210 min, respectively. This indicates that Rhodamine 110 absorption is not rapid after ingestion, as it took over 2 h to be absorbed from the intestines into the blood. The areas under the concentration–time curves (AUCs) for the two dosages are 138.1±20.3 and 444.0±170.8 h ng/mL. The pharmacokinetic data demonstrate that the AUC is proportional to the administered oral dose of Rhodamine 110 (3 mg/kg and 10 mg/kg). Furthermore, the clearance (Cl) of the two orally administered doses is 7.94 and 8.61 mL/min/kg, respectively.
報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
2024/08/19 | 41907 | 羅丹明110(99%) Rhodamine 110, 98+%, pure, laser grade | 13558-31-1 | 500mg | 2707元 |
2024/08/19 | 41907 | 羅丹明110(99%) Rhodamine 110, 98+%, pure, laser grade | 13558-31-1 | 2.5g | 8333元 |
2024/08/19 | HY-D0817 | 羅丹明 Rhodamine 110 | 13558-31-1 | 50mg | 500元 |