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135-87-5

中文名稱(chēng) 鹽酸哌羅克生
英文名稱(chēng) 1-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]piperidinium chloride
CAS 135-87-5
分子式 C14H20ClNO2
分子量 269.767
MOL 文件 135-87-5.mol
更新日期 2024/12/24 22:20:06
135-87-5 結(jié)構(gòu)式 135-87-5 結(jié)構(gòu)式

基本信息

中文別名
鹽酸吡哌咯生
鹽酸哌羅克生
英文別名
933F
piperoxan.HC
piperoxan.HCl
933F Hydrochloride
Benodaine hydrochloride
Piperoxane hydrochloride
Piperoxan (hydrochloride)
Benzodioxane hydrochloride
2-Piperidinomethyl-1,4-benzodioxan hydrochloride
Piperoxan hydrochloride (Benodaine hydrochloride)
所屬類(lèi)別
生物化工:激動(dòng)劑抑制劑

物理化學(xué)性質(zhì)

熔點(diǎn)229-231 °C
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度Chloroform: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
形態(tài)固體
顏色White to off-white

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302
毒性LD50 oral in mouse: 502mg/kg
鹽酸哌羅克生價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱(chēng)CAS號(hào)包裝價(jià)格
2024/11/08HY-100850鹽酸哌羅克生
Piperoxan hydrochloride
135-87-55mg1200元
2024/11/08HY-100850鹽酸哌羅克生
Piperoxan hydrochloride
135-87-510mM * 1mLin DMSO1320元
2024/11/08HY-100850鹽酸哌羅克生
Piperoxan hydrochloride
135-87-510mg1800元

常見(jiàn)問(wèn)題列表

生物活性
Piperoxan hydrochloride (Benodaine, Fourneau 933, F933, DL-Piperoxan) 是 α2 (alpha 2) adrenoceptor 的拮抗劑。
靶點(diǎn)
TargetValue
α2 adrenoceptor
()
體外研究

When the medulla is superfused with α 2 adrenoceptor antagonist Piperoxane (50 μM; 5 min) while the pons is with artificial cerebrospinal fluid (ACSF), the three inactive preparations display rhythmic phrenic bursts at a low frequency (2-4 c/min), and the phrenic burst frequency of the 12 active ones significantly increases during the last 3 min of Piperoxane applications (163±12% of the previous mean frequency). In active medullary preparations, the effects of NA applications (25 μM; 5 min) are compared when the preparations sre superfused either by ACSF (n=8) or by the α2 adrenoceptor antagonist Piperoxane (50 μM; PIP-ACSF; n=5). NA applications either alone (NA-ACSF) or with Piperoxane (PIP-ACSF+NA) significantly increases the phrenic burst frequency. However, the blockage of the medullary α2 adrenoceptors by Piperoxane potentiates a phrenic burst frequency increase: during the fifth minute of NA applications, the phrenic burst frequency reached 171±11% of the mean control value when ACSF is applied alone and 234±21% of the mean control value when PIP-ACSF is applied in control condition.

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