133550-34-2
中文名稱
TYRPHOSTIN AG 555
英文名稱
TYRPHOSTIN B46
CAS
133550-34-2
分子式
C19H18N2O3
分子量
322.36
MOL 文件
133550-34-2.mol
更新日期
2025/01/12 18:03:38
133550-34-2 結(jié)構(gòu)式
基本信息
中文別名
化合物AG 555(E)-2-氰基-3-(3,4-二羥基苯基)-N-(3-苯基丙基)丙烯酰胺
英文別名
AG 555AG 555, >98%
TYRPHOSTIN B46
TYRPHOSTIN AG 555
TYRPHOSTIN AG 555, >98%
AG 555 (Tyrphostin AG 555)
TYRPHOSTIN AG 555
TYRPHOSTIN AG-555
TYRPHOSTIN AG555
N-(3-PHENYLPROPYL)-3,4-DIHYDROXY-ALPHA CYANOCINNAMIDE
ALPHA-CYANO-(3,4-DIHYDROXY)-N-(3-PHENYLPROPYL)CINNAMIDE
N-(3'-PHENYLPROPYL)-3,4-DIHYDROXYBENZYLIDENECYANOACETAMIDE
物理化學性質(zhì)
沸點621.1±55.0 °C(Predicted)
密度1.273±0.06 g/cm3(Predicted)
儲存條件Inert atmosphere,Store in freezer, under -20°C
溶解度DMSO or ethanol: soluble
酸度系數(shù)(pKa)8.82±0.10(Predicted)
形態(tài)粉末
顏色Light yellow to yellow
常見問題列表
生物活性
AG-555 (Tyrphostin B46)是酪氨酸激酶抑制劑，可與拓撲異構(gòu)酶I直接相互作用，因而阻止DNA松弛。它抑制EGFR，IC50為0.7 μM。靶點
| Target | Value |
|
EGFR
(Cell-free assay) | 0.7 μM |
體外研究
AG 555 (100 μM) inhibits both the early stages (integration process) and the late stages (viral protein synthesis) in the virus life cycle.
Tyrphostins AG555, which blocks Cdk2 activation, induces growth arrest of immortalized cells at G1-S and early S and is very effective in arresting the growth of EGFR overexpressor cells.
Tyrphostin AG 555 can selectively suppress BPV-1 transcription through MAP kinase pathway activation and binding of phosphorylated Jun/ATF-2 at a novel intragenic regulatory sequence.
Cell Proliferation Assay
| Cell Line: | NIH/3T3 uninfected cells and NIH/3T3-Mo-MuLV chronically infected cells. |
| Concentration: | 100 μM. |
| Incubation Time: | 1 hour. |
| Result: | Inhibited Mo-MuLV proviral DNA integration. |