121288-39-9
121288-39-9 結(jié)構(gòu)式
基本信息
中文別名
洛索立賓7-烯丙基-8-氧代鳥苷
7-烯丙基-7,8-二氫-8-氧代鳥苷
7-烯丙基-7,8-二氫-8-羰基鳥苷
7-烯丙基-2-氨基-9-((2R,3R,4S,5R)-3,4-二羥基-5-(羥甲基)四氫呋喃-2-基)-1H-嘌呤-6,8(7H,9H)-二酮
英文別名
RWJ 21757Loxoribine
7,8-Dihydro-8-oxo-7-allyl-guanosine
7-Allyl-7,8-dihydro-8-oxoguanosine 95%
7-ALLYL-7 8-DIHYDRO-8-OXOGUANOSINE 95
7,8-Dihydro-8-oxo-7-(2-propenyl)guanosine
Guanosine, 7,8-dihydro-8-oxo-7-(2-propenyl)-
7,8-dihydro-8-oxo-7-allyl-guanosine, Loxoribine
Guanosine, 7,8-dihydro-8-oxo-7-(2-propen-1-yl)-
7-Allyl-7,8-dihydro-8-oxoguanosine (Loxoribine)
所屬類別
生物化工：核苷中間體物理化學(xué)性質(zhì)
熔點227-230 °C(lit.)
密度1.92±0.1 g/cm3(Predicted)
儲存條件Desiccate at +4°C
溶解度溶于 DMSO（高達 25 mg/ml）。
酸度系數(shù)(pKa)10.29±0.20(Predicted)
形態(tài)白色至類白色固體
顏色白色
旋光性 (optical activity)[α]21/D 32°, c = 1 in H2O
穩(wěn)定性DMSO中的溶液可在-20°下穩(wěn)定儲存3個月。
常見問題列表
用途
洛索立賓在抗腫瘤反應(yīng)中充當(dāng)合成佐劑。生物活性
Loxoribine (7-Allyl-8-oxoguanosine) 是一種鳥苷類似物，具有抗病毒和抗腫瘤活性。Loxoribine 是一種口服生物可利用、選擇性的 TLR7 激動劑。靶點
TLR7
體外研究
Loxoribine induces maturation of human monocyte-derived dendritic cells DCs and stimulates their Th-1- and Th-17-polarizing capability.
Loxoribine (250 μM; 48 hours) stimulates maturation of MoDCs as shown by up-regulation of CD80, CD83, CD40, CD54 and CCR7.
loxoribine activates cells of the innate immune system selectively via the Toll-like receptor (TLR) 7/MyD88-dependent signaling pathway.
體內(nèi)研究
Loxoribine (2 mg; s.c.or i.v.) activates murine natural killer (NK) cells in vivo.
| Animal Model: | 8-12 weeks male CBA/J mice |
| Dosage: | 2 mg |
| Administration: | Subcutaneous or intravenous injection |
| Result: | activates murine natural killer (NK) cells in vivo. |