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118081-34-8

中文名稱 頭孢布烯二水合物
英文名稱 Ceftibuten dihydrate
CAS 118081-34-8
分子式 C15H14N4O6S2.2H2O
分子量 446.459
MOL 文件 118081-34-8.mol
更新日期 2025/01/20 11:40:09
118081-34-8 結(jié)構(gòu)式 118081-34-8 結(jié)構(gòu)式

基本信息

中文別名
孢布烯二水合物
頭孢布烯二水合物
頭孢布坦(頭孢布烯)
頭孢布烯(頭孢布坦)
(+)-(6R,7R)-7-[2-(2-氨基-1,3-噻唑-4-基)-4-羧基-2-丁烯酰胺]]-8-氧-5-硫-1-氮雙環(huán)[4.2.0]辛-2-烯-2-羧酸二水物
英文別名
Cetb
Cedax
Seftem
D02121
Sch-39720
Cedax (tn)
Cedax-13C3
Seftem (tn)
S 7432-13C3
Ceftibuten (jp15)

物理化學(xué)性質(zhì)

熔點(diǎn)>180°C (dec.)
儲(chǔ)存條件-20°C冷凍

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS02
警示詞危險(xiǎn)
危險(xiǎn)性描述H225

應(yīng)用領(lǐng)域

用途1
用于合成有機(jī)原料或藥物中間體;科研單位合成研究"

常見問題列表

生物活性
Ceftibuten (Sch39720) dihydrate 是一種具有口服活性的頭孢菌素,在體外對(duì)多種革蘭氏陰性和某些革蘭氏陽(yáng)性病原體具有較強(qiáng)的抗菌活性。
體外研究

Ceftibuten (Sch39720) is highly active against Haemophilus influenza , Escherichia coli , Klebsiella sp., and Proteus sp. and moderately active against Serratia sp. and Streptococcus pyogenes . Ceftibuten is relatively inactive against enterococci and staphylococci and is only weakly active against Pseudomonas aeruginosa and obligate anaerobes. It is also stable in the presence of most β-lactamase-producing organisms except β Bacteroides fragilis . Ceftibuten is very active against strains of the family Enterobacteriaceae (mean MIC for 90% of strains=0.25 μg/ml) but less active against Campylobacterjejuni (mean MIC for 90% of strains=16.0 μg/ml).

體內(nèi)研究

Ceftibuten, a biologically stableβ-lactam antibiotic, has been shown to be transported by the small peptide transport system, to have relatively high affinity for the carrier and to show clear stereoselective and proton-gradient dependent transport characteristics in rat intestinal brush-border membrane vesicles.

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