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118021-35-5

中文名稱 (S)-(+)-2-氨基-3-(2-氨基乙氧基)丙酸賴氨酸
英文名稱 O-(2-AMINOETHYL)-L-SERINE HYDROCHLORIDE
CAS 118021-35-5
分子式 C5H13ClN2O3
分子量 184.62
MOL 文件 118021-35-5.mol
118021-35-5 結(jié)構(gòu)式 118021-35-5 結(jié)構(gòu)式

基本信息

中文別名
L-4-噁溶菌素鹽酸鹽
O-(2-氨乙基)-L-絲氨酸鹽酸鹽
間-(2-氨基乙基)-L-絲氨酸鹽酸鹽
(S)-(+)-2-氨基-3-(2-氨基乙氧基)丙酸賴氨酸
(S)-(+)-2-氨基-3-(2-氨基乙氧基)丙酸 單鹽酸鹽
英文別名
L-4-OXALYSINE HCL
H-SER(ETNH2)-OH HCL
H-LYS[*4(<-O)]-OH HCL
4-OXY-L-LYSINE HYDROCHLORIDE
L-4-Oxalysine (hydrochloride)
O-(2-AMINOETHYL)-L-SERINE HYDROCHLORIDE
O-(2-AMINOETHYL)-L-SERINE HYDROCHLORIDE USP/EP/BP
(2S)-2-amino-3-(2-aminoethoxy)propanoicacid,hydrochloride
(S)-(+)-2-AMINO-3-(2-AMINOETHOXY)PROPANOIC ACID, MONOHYDROCHLORIDE
(S)-(+)-2-AMINO-3-(2-AMINOETHOXY)-PROPAN OIC ACID HYDROCHLORIDE, 98%
所屬類別
生物化工:賴氨酸類衍生物

物理化學(xué)性質(zhì)

熔點(diǎn)212-216 °C(lit.)
比旋光度+4.0~+8.0°(c=10,dilHCl)(D/20)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
形態(tài)Solid
顏色White to off-white

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H315-H335-H319
危險(xiǎn)品標(biāo)志Xi
危險(xiǎn)類別碼36/37/38
安全說明26-36
WGK Germany3
(S)-(+)-2-氨基-3-(2-氨基乙氧基)丙酸賴氨酸價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-U00097(S)-(+)-2-氨基-3-(2-氨基乙氧基)丙酸賴氨酸
L-4-Oxalysine hydrochloride
118021-35-51mg1000元

常見問題列表

生物活性
L-4-Oxalysine hydrochloride是從中國(guó)的鏈霉菌培養(yǎng)基中分離的天然物質(zhì),具有抗癌活性。
體外研究

Alpha-fetoprotein (AFP) is expressed in BEL-7404 human hepatoma cells and L-4-Oxalysine suppresses AFP mRNA expression in the cells. L-4-oxalysine functionally antagonizes the a-fetoprotein-induced suppression of the mitogen- and one-way mixed lymphocyte culture-induced proliferation of spleen lymphocytes and interleukin-6 production by these cells in mice bearing the hepatoma-22 tumor.

體內(nèi)研究

Tbe ultrastructural efects of different doses of L-4-Oxalysine on hepatocytes in mice are most serious at day 1 after stopping treatment. Mice are given ig L-4-oxalysine (I-677) 10, 50, and 100 mg/kg for 7 d. On day 8 the hepatocytes show accumulation of lipid droplets followed by loss of matrices in cytoplasm. The total area of lipid droplets is far less than 25% of mean section of hepatocytes. The injury of mitochondria and RER is only found in the groups of medium and high dose. L-4-oxalysine inhibits the proliferation of some mouse implanted tumors and pulmonary metastasis of mouse Lewis lung carcinoma.

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