1154-25-2
1154-25-2 結(jié)構(gòu)式
基本信息
MH 12-43
L 593754
ethylisopropylamiloride
5-(N-ETHYL-N-ISOPROPYL)AMILORIDE
AMILORIDE, 5-(N-ETHYL-N-ISOPROPYL)-
3-AMino-N-(aMinoiMinoMethyl)-6-chloro-5-[ethyl(1-Methylethyl)aMino]-
3-amino-6-chloro-N-(diaminomethylene)-5-[ethyl(isopropyl)amino]pyrazinamide
3-aMino-N-carbaMiMidoyl-6-chloro-5-(ethyl(isopropyl)aMino)pyrazine-2-carboxaMide
3-AMINO-N-(AMINOIMINOMETHYL)-6-CHLORO-5-[ETHYL(2-PROPYL)AMINO]-PYRAZINE-2-CARBOXAMIDE
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
| 報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-101840 | 5-(N-乙基-N-異丙基)阿米洛利 EIPA | 1154-25-2 | 5mg | 500元 |
| 2024/11/08 | HY-101840 | 5-(N-乙基-N-異丙基)阿米洛利 EIPA | 1154-25-2 | 10mM * 1mLin DMSO | 550元 |
| 2024/11/08 | HY-101840 | 5-(N-乙基-N-異丙基)阿米洛利 EIPA | 1154-25-2 | 10mg | 800元 |
常見問題列表
IC50: 10.5 μM (TRPP3 channel)
NHE
Macropinocytosis
In the presence of 100 μM EIPA, 10 μM benzamil, and 10 μM phenamil, 45 Ca 2+ uptake decreases from 79±9 to 46±4 (58% remaining), 27±4 (34%), 29±5 (37%), and 38±4 (48%) pmol/oocyte/30 min (n=6, P=0.008), respectively. It is found that EIPA, benzamil, and phenamil rapidly and reversibly block Ca 2+ -activated TRPP3 channel activation at -50 mV, with IC 50 s of 143±8 (n=36), 10.5±2.2 (n=28), 1.1±0.3 (n=30), and 0.14±0.04 μM (n=25), respectively. The number of autophagic vacuoles increases dramatically in the HAE and HPE groups after EIPA treatment compare with the HAN and HPN groups. EIPA regulates the initiation and maturation of the autophagy associated with amino acids in IEC-18 cells. In addition, the uptake of cinnamoylphenazine (CA-PZ) and neutral red (NR) is inhibited by EIPA.