111757-17-6
中文名稱
N-(2-pyridone-6-yl)-N',N'-di-n-propylformamidine
英文名稱
N-(2-pyridone-6-yl)-N',N'-di-n-propylformamidine
CAS
111757-17-6
分子式
C12H19N3O
分子量
221.3
MOL 文件
111757-17-6.mol
111757-17-6 結構式
基本信息
中文別名
化合物 T26997 英文別名
CGP 28014N-(2-pyridone-6-yl)-N',N'-di-n-propylformamidine
Methanimidamide, N'-(1,6-dihydro-6-oxo-2-pyridinyl)-N,N-dipropyl-
應用領域
用途一
CGP-28014 is a catechol-O-methyltransferase inhibitor potentially for the treatment of Parkinson's disease.Although CGP-28014 increases the renal excretion of both dopamine and dihydroxyphenylacetic acid (DOPAC) it does not affect renal sodium handling indicating a different mechanism of action. CGP-28014 significantly reduced the levels of homovanillic acid (HVA), but did not modify DA and 3,4-dihydroxyphenylacetic acid (DOPAC).