105637-50-1
中文名稱
ML-9鹽酸鹽
英文名稱
ML-9 HYDROCHLORIDE
CAS
105637-50-1
分子式
C15H18Cl2N2O2S
分子量
361.29
MOL 文件
105637-50-1.mol
更新日期
2024/10/31 10:02:21
105637-50-1 結(jié)構(gòu)式
基本信息
中文別名
ML-9鹽酸鹽1-(5-氯萘磺?；?-1H-六氫-1,4-二氮雜卓, 鹽酸鹽
1-(5-氯萘-1-磺?；?-1H-六氫-1,4-二吖庚因鹽酸鹽
英文別名
ML-9ML-9, HCl
ML-9 HYDROCHLORIDE
1-(5-CHLORONAPHTHALENE- SULFONYL)HOMOPIPERAZINE
1-(5-chloronaphthalene-1-sulfonyl)-1H-*hexahydro-
1-(5-CHLORONAPHTHALENE-1-SULFONYL)-1H-HE XAHYDRO-1,
1-(5-CHLORONAPHTHALENE-1-SULFONYL)HOMOPIPERAZINE, HCL
1-(chloronaphthalenesulfonyl)-1H-hexahydrodiazepine HCl
1-(5-CHLORONAPHTHALENESULFONYL)HOMOPIPERAZINE HYDROCHLORIDE
1-(5-CHLORONAPHTHALENE-1-SULFONYL)-1H-HEXAHYDRO-1,4-DIAZEPINE
物理化學(xué)性質(zhì)
熔點(diǎn)196-200
儲存條件2-8°C
儲存條件2-8°C
溶解度ethanol: 10 mg/mL
溶解度乙醇：10 mg/mL
形態(tài)powder
顏色white
安全數(shù)據(jù)
常見問題列表
生物活性
ML-9 HCl (ML-9 hydrochloride) 是一種有效的選擇性的 Akt kinase、myosin light chain kinase (MLCK) 和 stromal interaction molecule 1 (STIM1)。ML-9 HCl 也是 Ca2+-permeable channels 的有效抑制劑。ML-9 HCl 是一種靶向自噬和細(xì)胞死亡的親溶酶體劑。靶點(diǎn)
| Target | Value |
|
Akt
() | |
|
MLCK
() | |
|
STIM1
() | |
|
Ca2+-permeable channels
() |
體外研究
ML9 (0-100?μM; 0-24?hours) has no reduction in cardiomyocyte viability, 50-100?μM significantly induces cell death. ML9 (50?μM; 1-4?hours) significantly increases cleaved?caspase-3?levels, decreased STIM1 protein levels by about 42%.
Cell Viability Assay
| Cell Line: | Neonatal rat ventricular?myocytes?(NRVM)?cells |
| Concentration: | 0, 10, 50 and 100?μM |
| Incubation Time: | 0, 1, 4, 8 and 24?hours |
| Result: | Decreased cell viability at 50-100?μM concentration. |
Apoptosis Analysis
| Cell Line: | Neonatal rat ventricular?myocytes?(NRVM)?cells |
| Concentration: | 50?μM |
| Incubation Time: | 1, 4 and 8?hours |
| Result: | Induced cardiomyocyte death through?necrosis?and apoptosis. |