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ChemicalBook--->CAS DataBase List--->99291-24-4

99291-24-4

99291-24-4 Structure

99291-24-4 Structure
IdentificationMore
[Name]

Levodropropizine
[CAS]

99291-24-4
[Synonyms]

LEVODROPROPIZINE
(s)-3-(4-phenyl-1-piperazinyl)-1,2-propanediol
(S)-Dropropizine
(S)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol
Levodropropizine
[Molecular Formula]

C13H20N2O2
[MDL Number]

MFCD00866852
[Molecular Weight]

236.31
[MOL File]

99291-24-4.mol
Chemical PropertiesBack Directory
[Melting point ]

98-100°
[alpha ]

D25 -10° (c = 1.0 in ethanol)
[Boiling point ]

412.7±34.0 °C(Predicted)
[density ]

1.168±0.06 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

Acetonitrile (Slightly), Methanol (Slightly)
[form ]

neat
[pka]

14.21±0.20(Predicted)
[color ]

White to Off-White
[CAS DataBase Reference]

99291-24-4(CAS DataBase Reference)
Hazard InformationBack Directory
[Description]

Levodropropizine is an antitussive with antiinflammatory activity, the L-isomer of dropropizine. Compared with the racemate, levodropropizine is reported to have less sedative potential and better therapeutic index, while maintaining the the same efficacy levels as an antitussive and antiinflammatory.
[Originator]

Dompe (Italy)
[Uses]

receptor agonist, treatment of colds and allergic rhinitis
[Uses]

R-Form of Dropropizine (D681495). (R)-(+)-Dropropizine is a cough suppressive phenylpiperazine derivative. (R)-(+)-Dropropizine is an antitussive and central sedative therapeutic agent.
[Brand name]

Levotus
Safety DataBack Directory
[Toxicity]

LD50 in mice, rats (mg/kg): 1287.2, 886.6 orally; 408.0, 401.3 i.p. (Borsa)
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