| Identification | More | [Name]
4'-Bromoacetophenone | [CAS]
99-90-1 | [Synonyms]
2,4'-DIBROMOACETOPHENONE
2-BROMO-1-(4-BROMOPHENYL)ETHAN-1-ONE
2-BROMO-1-(4-BROMOPHENYL)ETHANONE
4'-BROMOPHENACYL BROMIDE
4-BROMOPHENACYL BROMIDE
4-Bromophenaeyl bromide
4,OMEGA-DIBROMOACETOPHENONE
AKOS BBS-00000865
ALPHA,4'-DIBROMOACETOPHENONE
ALPHA-4-DIBROMOACETOPHENONE
ALPHA,P-DIBROMOACETOPHENONE
A,P-DIBROMOACETOPHENONE
DIBROMOACETOPHENONE-2,4
GSK-3BETA INHIBITOR VII
OMEGA-BROMOACETOPHENONE
PBPB
P-BROMOPHENACYL BROMIDE
1-(4-bromophenyl)-ethanon
Acetophenone, 4'-bromo-
Ethanone,1-(4-bromophenyl)- | [EINECS(EC#)]
202-783-6 | [Molecular Formula]
C8H7BrO | [MDL Number]
MFCD00000200 | [Molecular Weight]
199.04 | [MOL File]
99-90-1.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystals or | [Melting point ]
108-110 °C(lit.)
| [Boiling point ]
255 °C(lit.)
| [density ]
1.64 | [refractive index ]
1.5540 (estimate) | [Fp ]
>230 °F
| [storage temp. ]
Store below +30°C. | [solubility ]
methanol: 0.1 g/mL, clear
| [form ]
Crystals or Crystalline Flakes | [color ]
White to light yellow | [Water Solubility ]
Soluble in Chloroform. Insoluble in water. | [Usage]
Intermediates of Liquid Crystals | [Detection Methods]
GC,NMR | [Merck ]
14,1403 | [BRN ]
386015 | [InChIKey]
WYECURVXVYPVAT-UHFFFAOYSA-N | [CAS DataBase Reference]
99-90-1(CAS DataBase Reference) | [NIST Chemistry Reference]
Ethanone, 1-(4-bromophenyl)-(99-90-1) | [EPA Substance Registry System]
99-90-1(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
C,Xi,Xn | [Risk Statements ]
R34:Causes burns.
R36/38:Irritating to eyes and skin .
R42/43:May cause sensitization by inhalation and skin contact .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S22:Do not breathe dust .
S36/37:Wear suitable protective clothing and gloves . | [RIDADR ]
UN 3261 8/PG 2
| [WGK Germany ]
2
| [RTECS ]
AM6950000
| [F ]
19-21 | [Hazard Note ]
Irritant | [TSCA ]
Yes | [HS Code ]
29147090 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Bromobenzene-->Aluminium chloride hexahydrate | [Preparation Products]
ETHYL 4-ACETYLBENZOATE-->5-(4-BROMO-PHENYL)-3H-THIENO[2,3-D]PYRIMIDIN-4-ONE-->ETHYL 2-AMINO-4-(4-BROMOPHENYL)-3-THIOPHENECARBOXYLATE-->1,3,5-Tris(4-bromophenyl)benzene-->4-(4-BROMOPHENYL)-1,2,3-THIADIAZOLE-->4-Acetylphenylboronic acid-->4-Acetyl-2-fluorobiphenyl-->1-(2-NITRO-BIPHENYL-4-YL)-ETHANONE-->1,3,5-Tris(p-formylphenyl)benzene-->4-Bromophenethyl alcohol-->1,4-Diacetylbenzene-->1-(2-amino[1,1'-biphenyl]-4-yl)ethan-1-one-->2-(4-BROMO-PHENYL)-1H-INDOLE-->2,4'-Dibromoacetophenone-->4-Bromomandelic acid-->1-(4-Bromophenyl)ethylamine hydrochloride-->4-ACETYLBENZALDEHYDE-->4'-BROMO-3-(4-METHYLPHENYL)PROPIOPHENONE |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystals or | [Uses]
Intermediates of Liquid Crystals | [Uses]
Possess activity against positive phototaxis of Chlamydomonas cells.
A fundamental starting material for organic synthesis. | [Preparation]
4'-Bromoacetophenone is synthesized by the reaction of bromobenzene and acetic anhydride in the presence of aluminum trichloride.
Add bromobenzene and dry carbon disulfide into the reactor, put in powdered anhydrous aluminum trichloride, heat until it starts to reflux, stop heating, add acetic anhydride dropwise, and then reflux for 1 hour after adding, steam out carbon disulfide, and put it while it is still hot. The reactant was poured into the hydrochloric acid ice-water mixture, filtered to dryness, and distilled under reduced pressure to obtain p-bromoacetophenone. | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 51, p. 5400, 1986 DOI: 10.1021/jo00376a064
Tetrahedron Letters, 26, p. 4657, 1985 DOI: 10.1016/S0040-4039(00)98778-1 | [Purification Methods]
Crystallise it from EtOH, MeOH or from pet ether (b 80-100o). [Tanner J Org Chem 52 2142 1987, Beilstein 7 IV 647.] |
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