| Identification | More | [Name]
4-Nitro-o-phenylenediamine | [CAS]
99-56-9 | [Synonyms]
1,2-DIAMINO-4-NITROBENZENE
2-amino-4-nitroaniline
3,4-Diaminonitrobenzene
4-NITRO-1,2-PHENYLENEDIAMINE
4-NITRO-2-PHENYLENEDIAMINE
4-NITRO-O-PHENYLDIAMINE
4-NITRO-O-PHENYLENEDIAMINE
c.i. 76020
JAROCOL 4NOPD
TIMTEC-BB SBB007571
1,2-Benzenediamine,4-nitro-
1,2-benzenediamine,-nitro-
2-Benzenediamine,4-nitro-1
4ndb
4-nitro-1,2-benzenediamine
4-nitro-1,2-diaminobenzene
4-nitro-1,2-fenylendiamin
4-nitro-2-benzenediamine
4-nitrobenzene-1,2-diamine
4-nitro-o-phenylenediamin | [EINECS(EC#)]
202-766-3 | [Molecular Formula]
C6H7N3O2 | [MDL Number]
MFCD00007724 | [Molecular Weight]
153.14 | [MOL File]
99-56-9.mol |
| Chemical Properties | Back Directory | [Appearance]
Orange-red powder | [Melting point ]
199-201 °C (lit.) | [Boiling point ]
276.04°C (rough estimate) | [density ]
1.3682 (rough estimate) | [refractive index ]
1.6910 (estimate) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
1 N HCl: ethanol, 1:1: soluble50mg/mL | [form ]
Powder | [pka]
2.06±0.10(Predicted) | [color ]
Brown-red | [Stability:]
Stable. Incompatible with strong acids, strong reducing agents, strong oxidizing agents, acid chlorides, acid anhydrides. | [Water Solubility ]
1.2 g/L (20 ºC) | [Merck ]
14,6623 | [BRN ]
608106 | [InChIKey]
RAUWPNXIALNKQM-UHFFFAOYSA-N | [CAS DataBase Reference]
99-56-9(CAS DataBase Reference) | [IARC]
3 (Vol. 16, Sup 7) 1987 | [EPA Substance Registry System]
99-56-9(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R43:May cause sensitization by skin contact.
R68:Possible risk of irreversible effects.
R40:Limited evidence of a carcinogenic effect.
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S22:Do not breathe dust . | [RIDADR ]
2811 | [WGK Germany ]
3
| [RTECS ]
ST2975000
| [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
II | [HS Code ]
29215119 | [Safety Profile]
Moderately toxic by ingestion. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. Questionable carcinogen. When heated to decomposition it emits toxic fumes of NOx,.
| [Hazardous Substances Data]
99-56-9(Hazardous Substances Data) | [Toxicity]
LD50 oral in rat: 681mg/kg |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Activated carbon,decolor-->2,4-Dinitroaniline-->Benzenamine, N-hydroxy-2,4-dinitro--->benzene-1,2,4-triyltriamine-->2,5-Dinitroaniline-->2-Chloro-5-nitro-benzamine-->2,4-DINITROACETANILIDE-->1-Methoxy-2,4-dinitrobenzene-->4'-Nitroacetanilide | [Preparation Products]
5-Amino-2-benzimidazolethiol-->5-BROMO-6-ISOTHIOCYANATE QUINOXALINE-->6-NITRO-1H-BENZOIMIDAZOLE-2-THIOL-->5-Bromoquinoxalin-6-amine-->2-MERCAPTO-5-NITROBENZIMIDAZOLE-->6-Aminoquinoxaline-->Platinum,dichlorobis(dimethylphenylphosphine)-, (SP-4-2)--->1,4-Diamino-2-nitrobenzene-->1H-Benzimidazole,1-methyl-5-nitro-(9CI)-->5-Nitrobenzimidazole-->4-(5-nitro-H-benzimidazol-2-yl)aniline |
| Hazard Information | Back Directory | [General Description]
Dark red needles or red solid. | [Reactivity Profile]
4-NITRO-O-PHENYLENEDIAMINE(99-56-9) is incompatible with strong oxidizing agents, strong acids, strong reducing agents, acid chlorides and acid anhydrides. | [Air & Water Reactions]
Insoluble in water. | [Fire Hazard]
Flash point data for this chemical are not available; however, 4-NITRO-O-PHENYLENEDIAMINE is probably combustible. | [Chemical Properties]
Orange-red powder | [Uses]
4-Nitro-1,2-phenylenediamine is a hair dye constituent with potential mutagenic activity. | [Application]
4-Nitro-1,2-phenylenediamine is a hair dye constituent with potential mutagenic activity. It is used in oxidation hair dye formulations at a maximum concentration of 1.0 %, which after mixing typically in a 1:1 ratio with hydrogen peroxide just prior to use, corresponds to a concentration of 0.5% upon application. | [Definition]
ChEBI: The primary amino compound that is 1,2-phenylenediamine (o-phenylenediamine) substituted at the 4- (para-) position by a nitro group. | [Preparation]
Prepared by reduction of 2,4-dinitroaniline using H2S in ammonia water. | [Production Methods]
Commercial production of 4-nitro-o-PDA was first reported
in the United States in 1946. Two U.S. companies were
reported to produce undisclosed amounts of the chemical in
1975. U.S. imports of 4-nitro-o-PDA were reported to be
about 1900 kg in 1973 and 1100 kg in 1975. 4-Nitro-o-PDAis
used in fur dyes, inks, and semipermanent yellow hair
coloring formulations requiring a yellow color component
that does not involve the use of hydrogen peroxide in the
color development.
Occupational exposure to 4-nitro-o-PDA may occur
through inhalation and dermal contact with this compound
at workplaces where p-PDA is produced or used. The general
population may be exposed to the compound via dermal
contact, primarily through the use of hair dyes containing
this compound. | [Biochem/physiol Actions]
4-Nitro-o-phenylenediamine is a direct-acting mutagen. | [Purification Methods]
Crystallise the diamine from water. [Beilstein 13 IV 75.] |
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