| Identification | More | [Name]
Di-o-tolylguanidine | [CAS]
97-39-2 | [Synonyms]
1,3-DI-(2-TOLYL)GUANIDINE
1,3-DI-ORTHOTOLYL-GUANIDINE
1,3-DI-O-TOLYLGUANIDINE
2,2'-DIMETHYLIMINOCARBANILIDE
DI-O-TOLYLGUANIDINE
DITOLYGUANIDINE
DOTG
DTG
N,N'-DI-ORTHO-TOLYLGUANIDINE
VANAX DOTG
1,3-Bis(o-tolyl)guanidine
1,3-di(2-tolyl)-guanidin
1,3-Di-o-tolyguanidine
1,3-di-o-tolyl-guanidin
1,3-ditolylguanidine
Accelerator DT
accelerator(dotg)
AcceleratorDOTG
Acrochem DOTG
Akrochem DOTG | [EINECS(EC#)]
202-577-6 | [Molecular Formula]
C15H17N3 | [MDL Number]
MFCD00008513 | [Molecular Weight]
239.32 | [MOL File]
97-39-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
176-178 °C(lit.) | [Boiling point ]
371.98°C (rough estimate) | [density ]
1.1000 | [vapor pressure ]
0Pa at 25℃ | [refractive index ]
1.4560 (estimate) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
water: soluble70mg/mL at 20°C | [form ]
solid | [pka]
10.32±0.10(Predicted) | [color ]
White | [Water Solubility ]
70mg/L at 20℃ | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. | [LogP]
2.9 at 25℃ | [CAS DataBase Reference]
97-39-2(CAS DataBase Reference) | [NIST Chemistry Reference]
Guanidine, 1,3-di-o-tolyl-(97-39-2) | [EPA Substance Registry System]
97-39-2(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
UN 2811 | [WGK Germany ]
3
| [RTECS ]
MF1400000
| [TSCA ]
Yes | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
29252900 | [Safety Profile]
Poison by ingestion and
intraperitoneal routes. When heated to
decomposition it emits toxic fumes of NOx. | [Hazardous Substances Data]
97-39-2(Hazardous Substances Data) |
| Hazard Information | Back Directory | [Description]
DTG (97-39-2) is an agonist of the sigma (σ) receptor1?with roughly equal potency against both subtypes (σ1 and σ2 IC50’s ~ 30nM)2. | [Uses]
DTG is a selective ligand for the sigma-binding site. DTG has high binding affinity. | [Definition]
ChEBI: 1,2-bis(2-methylphenyl)guanidine is a member of toluenes. | [General Description]
1,3-Di-o-tolylguanidine is a selective σ-receptor agonist. 1,3-Di-o-tolylguanidine is σ site ligand and its interaction with dopamine drugs were studied in Wistar rats and Albino Swiss mice. | [Flammability and Explosibility]
Nonflammable | [Biological Activity]
Displays high and roughly equal affinity for both σ 1 and σ 2 receptors. | [storage]
Store at RT | [Purification Methods]
The guanidine crystallises from aqueous EtOH. The sulfate has m 253-254o(dec, H2O). [Beilstein 12 H 803, 12 II 445, 12 III 1871, 16 IV 1764] | [References]
1) Weber?et al.?(1986),?1,3-Di(2-[5-3H]tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic opiates and antipsychotic drugs; Proc. Natl. Acad. Sci. USA,?83?8784
2) Scherz?et al.?(1990),?Synthesis and Structure-Activity Relationships of N,N’-Di-o-tolylguanidine Analogues, High-Affinity Ligands for the Haloperidol-Sensitive σ Receptor; J. Med. Chem.,?33?2421 |
|
|