| Identification | More | [Name]
5-Bromouridine | [CAS]
957-75-5 | [Synonyms]
5-BROMOURACIL-1-BETA-D-RIBOFURANOSIDE
(-)-5-BROMOURIDINE
5'-BROMOURIDINE
5-BROMOURIDINE
1-beta-ribofuranosyl-5-bromo-uracil
5-bromo-uridin
5-Bromouridine,98%
5-Bromouridine, 99+%
5-bromouracil-1-β-d-ribofuranoside
5-Bromo-D-uridine
5-BROMO-URIDINE(5-BRU)
5-BROMOURIDINE (5-BROMOURACIL-1-β-D-RIBOFURANOSIDE: 5-BRU)
5-BROMOURIDINE extrapure
5-Bromouracil-1-β-D-ribofuranoside, 5-Bromouridine
5-Bromo-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
5-BrU | [EINECS(EC#)]
213-486-6 | [Molecular Formula]
C9H11BrN2O6 | [MDL Number]
MFCD00006528 | [Molecular Weight]
323.1 | [MOL File]
957-75-5.mol |
| Chemical Properties | Back Directory | [Appearance]
WHITE FINE POWDER | [Melting point ]
180-182 °C (dec.) (lit.) | [alpha ]
-11 º (c=2 in H2O) | [density ]
1.9322 (rough estimate) | [refractive index ]
1.6520 (estimate) | [storage temp. ]
0-6°C | [solubility ]
Water (Sonicated) | [form ]
Solid | [pka]
7.73±0.10(Predicted) | [color ]
Off-White | [optical activity]
[α]22/D 11°, c = 2 in H2O | [Water Solubility ]
Insoluble in water. | [BRN ]
33664 | [CAS DataBase Reference]
957-75-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [RTECS ]
YU7300000
| [F ]
10 | [HS Code ]
29349990 |
| Hazard Information | Back Directory | [Description]
5-Bromouridine is an energy-related metabolite that is a precursor of uridine. 5-Bromouridine binds to the nuclear DNA in cells, where it can act as a transcriptional regulator. 5-Bromouridine is used in the treatment of malignant brain tumors, where it can inhibit tumor growth by binding to the dna of cancer cells and preventing the synthesis of proteins required for cell division. | [Chemical Properties]
WHITE FINE POWDER | [Uses]
5-Bromouridine is a uridine (U829910) derivative and is often incorporated into RNA in order to detect immunocytochemically and analyzed by cytometry. | [Uses]
5-Bromouridine is often incorporated into RNA in order to detect immunocytochemically and analyzed by cytometry. It possesses anti-viral activity and inhibits the activity of viruses such as human immunodeficiency virus. | [Definition]
ChEBI: A uridine having a bromo substituent at the 5-position. | [storage]
Store at -20°C | [Purification Methods]
Recrystallise it from 96% EtOH. UV max 279nm (log 3.95)in 2O pH 1.9. RF in n -BuOH/AcOH/H2O (4:4:1) is 0.49; in n-BuOH/EtOH/H2O (40:11:9) it is 0.46 and in isoPrOH/25%NH3/H2O (7:1:2) it is 0.53 using Whatman No 1 paper. [Pryst.s & Sorm Collect Czech Chem Commmun 29 2956 1964, Beilstein 31 H 24.] |
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