| Identification | Back Directory | [Name]
PCI 34051 | [CAS]
950762-95-5 | [Synonyms]
PCI 34051
PCI-34051
1-(4-methoxybenzyl)-N-hydroxy-1H-indole-6-carboxamide
N-hydroxy-1-(4-Methoxybenzyl)-1H-indole-6-carboxaMide
N-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide
1H-Indole-6-carboxamide, N-hydroxy-1-[(4-methoxyphenyl)methyl]- | [Molecular Formula]
C17H16N2O3 | [MDL Number]
MFCD11114393 | [MOL File]
950762-95-5.mol | [Molecular Weight]
296.321 |
| Chemical Properties | Back Directory | [density ]
1.25 | [storage temp. ]
2-8°C | [solubility ]
insoluble in H2O; insoluble in EtOH; ≥14.8 mg/mL in DMSO | [form ]
Powder | [pka]
9.16±0.30(Predicted) | [color ]
White to gray |
| Hazard Information | Back Directory | [Usage]
PCI-34051 is a potent, histone deacetylase 8 (HDAC8)-specific inhibitor. PCI-34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias. PCI-34051 did not affect other hematopoietic or solid tumor lines. PCI-34051 treatment has been shown to significantly reduce cholesterol accumulation in Niemann-Pick type C1 gene mutated human fibroblast. | [Uses]
PCI-34051 is a potent, histone deacetylase 8 (HDAC8)-specific inhibitor. PCI-34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias. PCI-34051 did not affect other hematopoietic or solid tumor lines. PCI-34051 treatment has been shown to significantly reduce cholesterol accumulation in Niemann-Pick type C1 gene mutated human fibroblast. | [Definition]
ChEBI: N-hydroxy-1-[(4-methoxyphenyl)methyl]-6-indolecarboxamide is an indolecarboxamide. | [Biological Activity]
pci-34051 is a potent, specific inhibitor of histone deacetylase 8 (hdac8) with greater than 200-fold selectivity over the other hdac isoforms, such as 1, 2, 3, 6 and 10. it induces caspase dependent apoptosis in cell lines derived from t-cell lymphomas or leukemias, but not in other hematopoietic or solid tumor lines. pci-34051 does not cause detectable histone or tubulin acetylation and also does not inhibit growth or induce apoptosis in normal cells such as pbmcs or fibroblasts. although a phospholipase c-gamma1 (plcgamma1) defective line is resistant, cells defective in t-cell receptor signaling are still sensitive to pci-34051 induced apoptosis. | [storage]
-20°C | [References]
[1]. s balasubramanian, j ramos, w luo, m sirisawad, e verner, j j buggy. a novel histone deacetylase 8 (hdac8)-specific inhibitor pci-34051 induces apoptosis in t-cell lymphomas. leukemia (2008) 22, 1026–1034.
[2]. sriram balasubramanian, erik verner, joseph j. buggy. isoform-specific histone deacetylase inhibitors: the next step? cancer letters. volume 280, issue 2, 8 august 2009, pages 211–221. |
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NCE Biomedical Co.,Ltd.
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