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ChemicalBook--->CAS DataBase List--->935273-79-3

935273-79-3

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    935273-79-3 Structure
    
                                
    
                                935273-79-3 Structure
                            
    
                            		
                    
    
                
    
                
    IdentificationBack Directory
    [Name]

    MK-4101
    [CAS]

    935273-79-3
    [Synonyms]

    MK-4101
    MK4101;MK 4101;MK-4101
    5-(3,3-Difluorocyclobutyl)-3-[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl]bicyclo[2.2.2]oct-1-yl]-1,2,4-oxadiazole
    1,2,4-Oxadiazole, 5-(3,3-difluorocyclobutyl)-3-[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl]bicyclo[2.2.2]oct-1-yl]-
    [Molecular Formula]

    C24H24F5N5O
    [MDL Number]

    MFCD30343842
    [MOL File]

    935273-79-3.mol
    [Molecular Weight]

    493.47
    Chemical PropertiesBack Directory
    [storage temp. ]

    Store at -20°C
    [solubility ]

    Soluble in DMSO
    [form ]

    A crystalline solid
    [color ]

    White to off-white
    Safety DataBack Directory
    [Symbol(GHS) ]


    GHS07
    [Signal word ]

    Warning
    Hazard InformationBack Directory
    [Biological Activity]

    mk-4101 is a hedgehog (hh) signaling pathway inhibitor.abnormal activation of the hedgehog (hh) signaling pathway is reported in the pathogenesis of various cancers, such as medulloblastoma and basal cell carcinoma.
    [in vitro]

    mk-4101 was found to target the hh pathway in tumor cells, with the maximum inhibitory effect on gli1. mk-4101 could also induce the deregulation of cell cycle and block of dna replication in tumors. in addition, members of the igf and wnt signaling pathways were among the most highly deregulated genes by mk-4101, indicating that the interplay among hh, igf, and wnt was critical in hh-dependent tumorigenesis [1].
    [in vivo]

    in a previous study, using neonatally irradiated ptch1(+/-) mice as a model of hh-dependent tumors, the in vivo effects of mk-4101 was investigated for the treatment of medulloblastoma and basal cell carcinoma. results showed a potent antitumor activity of mk-4101, achieved by the inhibition of proliferation and induction of extensive apoptosis. moreover, beside antitumor activity on transplanted tumors, mk-4101 was found to be highly efficacious against primary medulloblastoma and basal cell carcinoma in the cerebellum and skin [1].
    [target]

    TargetValue
     SMO 
     ()
    [IC 50]

    1.5 μmol/l for in mouse light ii cells by gli_luc assay
    [References]

    [1] filocamo g et al.  mk-4101, a potent inhibitor of the hedgehog pathway, is highly active against medulloblastoma and basal cell carcinoma. mol cancer ther. 2016 jun;15(6):1177-89.
    
                		
            
            
                
                
    
                    
                        
    
                            
                                
                                
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