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ChemicalBook--->CAS DataBase List--->91300-60-6

91300-60-6

91300-60-6 Structure

91300-60-6 Structure
IdentificationMore
[Name]

6-ANILINO-5,8-QUINOLINEDIONE
[CAS]

91300-60-6
[Synonyms]

LY 83583
91300-60-6
LY-83583 (LY83583)
6-ANILINO-5,8-QUINOLINEDIONE
6-ANILINO-5,8-QUINOLINEQUINONE
6-ANILINOQUINOLINE-5,8-QUINONE
6-(anilino)quinoline-5,8-dione
6-(phenylamino)quinoline-5,8-dione
6-(PHENYLAMINO)-5,8-QUINOLINEDIONE
LY 83583 - CAS 91300-60-6 - Calbiochem
5,8-Dihydro-5,8-dioxo-6-(phenylaMino)quinoline
6-(Phenylamino)-5,8-quinolinedione, LY-83,583
(4-methyl-2-oxo-1-benzopyran-7-yl)oxy-phenylphosphinic acid
5,8-Dihydro-5,8-dioxo-6-(phenylamino)quinoline, [(5,8-Dihydro-5,8-dioxoquinolin-6-yl)amino]benzene, 6-Anilinoquinoline-5,8-dione
[Molecular Formula]

C15H10N2O2
[MDL Number]

MFCD00210756
[Molecular Weight]

250.25
[MOL File]

91300-60-6.mol
Chemical PropertiesBack Directory
[Appearance]

Red-Brown Solid
[Melting point ]

184-185°C
[Boiling point ]

446.9±45.0 °C(Predicted)
[density ]

1.400±0.06 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

0.1 M HCl: 1 mg/mL
[form ]

solid
[pka]

-0.63±0.20(Predicted)
[color ]

violet
[Usage]

Inhibits nitric-oxide-induced activation of soluble guanylate cyclase (IC50=2) in a dose-dependent and reversible manner. It blocks acetylcholine induced vasorelaxation. Also an inhibitor of antigen-induced leukotriene release
[CAS DataBase Reference]

91300-60-6(CAS DataBase Reference)
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

R40:Limited evidence of a carcinogenic effect.
[Safety Statements ]

S36/37:Wear suitable protective clothing and gloves .
[WGK Germany ]

2
[HS Code ]

2933499090
Hazard InformationBack Directory
[Chemical Properties]

Red-Brown Solid
[Uses]

Inhibits nitric-oxide-induced activation of soluble guanylate cyclase (IC50=2) in a dose-dependent and reversible manner. It blocks acetylcholine induced vasorelaxation. Also an inhibitor of antigen-induced leukotriene release
[Uses]

Inhibits nitric-oxide-induced activation of soluble guanylate cyclase (IC50=2μM) in a dose-dependent and reversible manner. It blocks acetylcholine induced vasorelaxation. Also an inhibitor of antigen-induced leukotriene release.
[Uses]

LY83583 is an inhibitor of soluble guanylate cyclase and of cGMP production. It inhibits soluble guanylate cyclase in human platelets with an IC50 value of 2 μM. LY83583 also inhibits leukotriene synthesis in guinea pig lung and rat peritoneal cells with an IC50 value of 1.8 μM and is a noncompetitive inhibitor of glutathione reductase in bovine intestinal mucosa with a Ki value of 3 μM.[Cayman Chemical]
[Definition]

ChEBI: A quinolone that is quinoline-5,8-dione in which the hydrogen at position 6 is replaced by an anilino group.
[Biological Activity]

Primary Target
soluble guanylate cyclase''Target IC50: 2 μM against soluble guanylate cyclase
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

91300-60-6(sigmaaldrich)
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