| Identification | Back Directory | [Name]
NU1025 | [CAS]
90417-38-2 | [Synonyms]
NU1025
NSC 696807
NU1025
(NSC 696807)
PARP Inhibitor VI, NU1025
8-Hydroxy-2-methylquinazolin-4(3H)
8-HYDROXY-2-METHYLQUINAZOLINE-4-ONE
8-HYDROXY-2-METHYL-4(3H)-QUINAZOLINONE
8-HYDROXY-2-METHYLQUINAZOLIN-4[3H]-ONE
8-hydroxy-2-methyl-1H-quinazolin-4-one
8-hydroxy-2-methylquinazolin-4(1H)-one
4(3H)-Quinazolinone, 8-hydroxy-2-Methyl-
8-Hydroxy-2-methylquinazoline-4-one ,97% | [Molecular Formula]
C9H8N2O2 | [MDL Number]
MFCD00942555 | [MOL File]
90417-38-2.mol | [Molecular Weight]
176.17 |
| Chemical Properties | Back Directory | [Appearance]
Off-White to Pale Yellow Solid | [Melting point ]
253-258°C | [Boiling point ]
345.4±44.0 °C(Predicted) | [density ]
1.42 | [storage temp. ]
−20°C
| [solubility ]
DMSO: 35 mg/mL, soluble
| [form ]
solid
| [pka]
8.68±0.20(Predicted) | [color ]
off-white | [CAS DataBase Reference]
90417-38-2 |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White to Pale Yellow Solid | [Uses]
A potent inhibitor of poly (ADP-ribose) polymerase (PARP). Ki and IC50 values are 48 and 400 nM respectively | [Definition]
ChEBI: A member of the class of quinazolines that is quinazolin-4(1H)-one substituted by a hydroxy group at position 8 and a methyl group at position 2. It has been shown to exhibit inhibitory activity against poly(ADP-ribose) polymerase. | [Uses]
NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC50 = 400 nM). It enhances the cytotoxicity of γ-irradiation and certain anticancer drugs. NU 1025 is also used to study the regulation of deoxyribonucleic acid repair by PARP enzymes.[Cayman Chemical] | [Biological Activity]
Novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP). K i and IC 50 values are 48 and 400 nM respectively. | [Description]
NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC50 = 400 nM).1 It enhances the cytotoxicity of γ-irradiation and certain anticancer drugs.2,3 NU 1025 is also used to study the regulation of deoxyribonucleic acid repair by PARP enzymes.4 | [storage]
Store at RT |
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