| Identification | Back Directory | [Name]
Tween 80 | [CAS]
9005-65-6 | [Synonyms]
svo9
to10
Tween
mo55f
monitan
crill10
crill11
sorlate
tween81
tween80a
crillet4
crills10
durfax80
nikkolto
olothorb
TWEEN 80
FEMA 2917
hodagsvo9
atlox1087
romulgino
sorbont80
emsorb6900
nci-c60286
nikkolto10
'TWEEN' 80
TWEEN 80KR
Ester Blend
TWEEN(R) 80
TWEEN(R) 81
TWEEN NO 80
atlox8916tf
capmulpoe-o
sorbital020
POLYSORBATE
MONTANOX 80
atolox8916tf
polysorban80
TWEEN(TM) 80
TWEEN(TM) 81
TWEEN(TM) 85
Tween 80 1LT
armotanpmo-20
protasorbo-20
POLYSORBATE 80
EmulsifierT-80
TWEEN(1)(R) 80
POLYSORBATE 81
EMALEX ET-8020
EMALEX ET-8040
Tween 80 1 lTr
Vinylube(R) 38
TWEEN 80 EP, NF
glycosperseo-20
POLYSORBATUM 80
glycosperseo-20x
drewmulsepoe-smo
polysorbate80bpc
Lonzest(R) SMO-5
tween 80solution
POLYSORBATE,80,NF
Lonzest(R) SMO-20
tween 80 solution
polysorbate80,usp
POLYSORBATE 80 VG
Tween\(rg 80, 94%
Tween-80(Tween80)
POLYOXYETHYLENE 20
glycosperseo-20veg
Glycolube(R) AFA-1
POLYSORBATE,80,FCC
polysorbate80b.p.c.
sorbimacrogololeate
SURFACT-AMPS(TM) 80
SORBITAN MONOOLEATE
MONTANOX(R) 80 DF VG
polysorbate80,u.s.p.
Polysorbate 80 (2 g)
Polysorbate 80 (AS)
POLYSORBAT 80, PH EUR
glycol(polysorbate80)
PEG-3 SORBITAN OLEATE
PEG-6 SORBITAN OLEATE
Polysorbate 80, Ph Eur
POLYSORBATE,80,NF(BULK
TWEEN(R) 80 solution
PROTEIN SOLUBILIZER 80
sorbimacrogololeate300
Glycosperse(R) O-20 KFG
TWEEN(R) POLYSORBATE 80
Tween? 80 (Polysorbate)
POLYSORBATE 80 extrapure
sorethytan(20)monooleate
TWEEN(R) 80 375-480 MPA.S
Tween 80 (Polysorbate 80)
Polysorbate 80 (2 g) (AS)
Tween 80, synthesis grade
TRYPTONE SOY BROTH 20X15ML
TRYPTONE SOY BROTH 120X15ML
POE(40) SORBITAN MONOOLEATE
POE (20) SORBITAN MONOOLEATE
ethoxylatedsorbitanmonooleate
polyoxyethylenesorbitanoleate
TWEEN 80, PHARMACEUTICAL GRADE
TWEEN 80, CELL CULTURE REAGENT
Sorbitan monooleate ethoxylate
ANAPOE-80 (TWEEN 80) Screw Cap
Polysorbate 80 for biochemistry
POLYOXYETHYLENE (20) MONOOLEATE
CHROMOGENIC SELECTIVE E.COLI 55MM
Sorbitan Monooleatepolyoxyethylene
Polyoxyethylene 20 sorbitan oleate
POLYOXYETHYLENESORBITAN MONOOLEATE
POLYOXYETHYLENE ORBITANE MONOOLEATE
Tween 80 (Polysorbate) Ph EUR,jp,nf
TWEEN(R) 80 Vetec(TM) reagent grade
TWEEN(R) 80 BIOXTRA, VISCOUS LIQUID
TWEEN(R) 80 SOLUTION, 10%, LOW PEROX
TWEEN(R) 80, SUITABLE FOR CELL CULTU
POLYOXYETHYLENESORBITAN MONOOLEATE T
POLYOXYETHYLENESORBITAN MONOOLEATE*M
polyethyleneoxidesorbitanmono-oleate
POLYOXYETHYLENE(6)SORBITANMONOOLEATE
po1yoxyethylene(20)sorbitan monooleate
POLYOXYETHYLENE SORBITAN MONOOLEATE, N
POLYETHYLENE GLYCOL SORBITAN MONOOLEATE
Poly(20)oxyethylene sorbitan monooleate
CCA COLIFORMS CHROMOGENIC A. (ISO) 55MM
Polyoxyethylene (20) sorbitan Monoleate
POLYSORBATE 80 CRILLET 4HP, 200 ML,EXCIP
POLYOXYETHYLENE SORBITAN MONOOLEATE*POLY
POLYOXYETHYLENE (20) SORBITAN MONOOLEATE
sorbitan,monooleatepolyoxyethylenederiv.
sorbitan,monooleate,polyoxyethylenederivs
Tween 80 (Trademark of ICI America, Inc.)
POLYOXYETHYLENE GLYCOL SORBITAN MONOOLEATE
POLYOXYETHYLENESORBITAN MONOOLEATE*TWEEN 80
POLYOXYETHYLENESORBITAN MONOOLEATE*(TWEE N 81)
Tween80(Polyoxyethylene-20-SorbitanMonooleate)
ProteinSolubilizer80,ReadytouseAmpules,Sterile
POLYOXYETHYLENESORBITAN MONOOLEATE*SIGMA ULTRA
Tween 80 (=Polyoxyethylene Sorbitan Monooleate)
polyethylene glycol sorbitan monooleate solution
POLYOXYETHYLENESORBITAN MONOOLEATE, LOW PEROXIDE
Sorbitan monooleate, ethoxylated, EO 4 or 20 mol
Polyoxyethylenesorbitan monooleate, TWEEN(R) 80
POLYOXYETHYLENESORBITAN MONOOLEATE,*TWEE N 80R, LOW
POLYOXYETHYLENESORBITAN MONOOLEATE*(TWEE N 80) INSEC
POLYOXYETHYLENE SORBITAN MONOOLEATE*(TWE EN 80), LOW
POLYOXYETHYLENE-SORBITAN MONOOLEATE*(TWE EN 80) CELL
POLYOXYETHYLENESORBITAN MONOOLEATE*MOLEC ULAR BIOLOG
POLYOXYETHYLENE SORBITAN MONOOLEATE*TWEE N 80K, POLY
TWEEN(R) 80 SOLUTION, ~10% IN WATER, PGE W. 6 X 10 ML
Polysorbate 80,Polyoxyethylenesorbitan monooleate, TWEEN 80
sorbitanmono-9-octadecenoatepoly(oxy-1,2-ethanediyl)derivatives
mono-9-octadecenoate,poly(oxy-1,2-ethanediyl)derivs,(z)-sorbita
mono-9-octadecenoate,poly(oxy-1,2-ethanediyl)derivs.,(z)-sorbita
mono-9-octadecenoate,poly(oxy-1,2-ethanediyl)derivs.,(Z)-Sorbitan
Sorbitan, mono-(9Z)-9-octadecenoate, poly(oxy-1,2-ethanediyl) derivs.
Polyoxyethylenesorbitan monooleate, Polysorbatum 80, TWEEN(R) 80
Tween 80 (=Polyoxyethylene Sorbitan Monooleate) [for Biochemical Research]
Polysorbate 80,Polyoxyethylenesorbitan monooleate, Polysorbatum 80, TWEEN 80
POLYOXYETHYLENE SORBITAN MONOOLEATE TWEE N 80KR, POLYSORBATE 80, LOW PEROXIDE,
Polyethylene glycol sorbitan monooleate solution, Polyoxyethylenesorbitan Monooleate
Polyethylene glycol sorbitan monooleate, Polyoxyethylenesorbitan monooleate, Polysorbate 80
Polyethylene glycol sorbitan monooleate, Polyoxyethylenesorbitan monooleate, Polysorbate 80, Tween(R) 80KR
TWEEN 80,POE (20) sorbitan monooleate, Polyethylene glycol sorbitan monooleate, Polyoxyethylenesorbitan monooleate, Polysorbate 80 | [EINECS(EC#)]
500-019-9 | [Molecular Formula]
C24H44O6 | [MDL Number]
MFCD00082107 | [Molecular Weight]
428.6 |
| Chemical Properties | Back Directory | [Appearance]
Yellow to amber liquid | [Melting point ]
-25 °C | [Boiling point ]
>100°C | [density ]
1.08 g/mL at 20 °C
| [vapor pressure ]
<1 mm Hg ( 20 °C)
| [FEMA ]
2917 | [refractive index ]
n20/D 1.473
| [Fp ]
>230 °F
| [storage temp. ]
Store at RT. | [solubility ]
DMSO (Soluble), Methanol (Slightly) | [form ]
viscous liquid
| [color ]
Amber | [Specific Gravity]
1.080 (25/4℃) | [Odor]
mild alcoholic | [PH]
5-7 (50g/l, H2O, 20℃) | [PH Range]
6 | [Odor Type]
alcoholic | [Water Solubility ]
5-10 g/100 mL at 23 ºC | [Merck ]
14,7582 | [Hydrophilic-Lipophilic Balance (HLB)]
10 | [LogP]
4.392 (est) | [EPA Substance Registry System]
Sorbitan, mono-(9Z)-9-octadecenoate, poly(oxy-1,2-ethanediyl) derivs.(9005-65-6) |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow to amber liquid | [Uses]
A non ionic detergent for cell lysis | [Uses]
Glycolube(R) AFA-1 is used as an antistat for PVC and as an antifog for PP, PE, PVC, PS. | [Uses]
Glycosperse(R) O-20 KFG is used as an emulsifier (ice cream, whipped topping) and as a solubilizing and dispersing agent in pickles and special vitamin-mineral preparations. Product Data Sheet | [Uses]
Lonzest(R) SMO-20 is used as an emulsifier for textiles, personal care and industrial applications. | [Uses]
Lonzest(R) SMO-5 is a general purpose mid-range HLB, ethoxylated, nonionic surfactant suggested for use in textile chemicals (emulsifier, lubricant), household products and cosmetic formulations (o/w emulsifier, viscosity modifier). | [Uses]
Vinylube(R) 38 is an external lubricant for PVC bottle, film, and sheet components with excellent processing abilities and final clarity. It is also used as an antistatic agent. Product Data Sheet | [General Description]
Amber-colored viscous liquid. pH (5% aqueous solution) 5-7. Faint odor and bitter taste. | [Air & Water Reactions]
Water soluble. | [Reactivity Profile]
Tween 80 is incompatible with strong alkalis and oxidizers. | [Fire Hazard]
Tween 80 is probably combustible. | [Characteristics]
Tween-80, commercially known as Polysorbate-80, is a viscous, water-soluble Yellow to amber liquid derived from polyethoxylated sorbitan and oleic acid. Tween-80 is structurally similar to the (polyethylene) glycols and used both in injections (0.8-8.0%) and in oral suspension (0.375% w/v). A number of anticancer drugs can be formulated by Tween-80. Typical examples include etoposide and minor groove-binding cyclopropylpyrroloindole analogues like carzelesin. | [Definition]
ChEBI: A polymer composed of PEG-ylated sorbitan, where the total number of poly(ethylene glycol) units is 20 (w + x + y + z = 20) and a single terminal is capped by an oleoyl group. | [Brand name]
Sorlate (Abbott); Tween 80 (ICI Americas). | [Biochem/physiol Actions]
Polysorbates is used as emulsifiers, dissolving agents and stabilizer for essential oils, topical application and medical infusions including intravenous, subcutaneous or intramuscular administration. | [Pharmacokinetics]
Polysorbate 80 (Tween 80) is rapidly removed from systemic circulation. The polysorbate 80 plasma concentration-time curve (AUC) in a patient administered an intravenous (IV) infusion of docetaxel 35 mg/m2 (polysorbate 80 1.75 g) showed a polysorbate 80 peak concentration of 304 μg/ml. The AUC for polysorbate 80 was 321.7 mg h/ml, with a short disposition half-life of 1.07 h and a total plasma clearance of 5.44 l/h. The distribution of polysorbate 80 at steady state was similar to the total blood volume (4.16 l), suggesting that polysorbate 80 circulates as large micelles and does not significantly distribute outside the central compartment. In vitro studies suggest that polysorbate 80 is metabolized by rapid carboxylesterase-mediated hydrolysis[1]. |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
22-36/37/38-37/38-41 | [Safety Statements ]
24/25-36/37/39-36-26 | [WGK Germany ]
1
| [RTECS ]
WG2934000
| [F ]
3 | [TSCA ]
Yes | [HS Code ]
34021300 | [Safety Profile]
Moderately toxic by
intravenous route. Mildly toxic by ingestion.
Experimental reproductive effects.
Questionable carcinogen with experimental
tumorigenic data. Human mutation data
reported. An eye irritant. When heated to
decomposition it emits acrid smoke and
irritating fumes. | [Hazardous Substances Data]
9005-65-6(Hazardous Substances Data) | [Toxicity]
LD50 in mice, rats (ml/kg): 7.5, 6.3 i.p. (Varma) |
| Questions And Answer | Back Directory | [Description]
Tween 80, commonly known as polysorbate 80, is a synthetic compound that is widely applied in a variety of fields, including foods, medicines, and cosmetics. In food production, it is commonly used as a defoamer for the fermenting process of some wines and as a emulsifier in ice-cream or “puddings” to keep the creamy texture without separating. Tween 80 is also extensively applied in pharmaceutical industry, where it can be found in some vaccines, vitamins and supplements. It is an effective excipient to stabilize aqueous formulations of medications for parenteral administration and to improve the consistency of gel capsules, thus to make pills disperse in the stomach. Besides, it commonly serve as a surfactant and solubilizer in the production of soaps and cosmetics, which is effective to help dissolve ingredients and make products look creamier and more attractive. In laboratory, it is occasionally used for a test to identify the phenotype of a strain or isolate, such as mycobacteria.
| [Chemical Properties]
TWEEN 80 is a polyethylene sorbitol ester, with a calculated molecular weight of 1,310 daltons, assuming 20 ethylene oxide units, sorbitol, and 1 oleic acid as the primary fatty acid.
Tweens are a series of nonionic surfactants derived from sorbitan esters. They are soluble or dispersible in water but differ widely in organic and oil solubilities. TWEEN 80 has been widely used in biochemical applications including: solubilizing proteins, isolating nuclei from cells in culture,5 growing of tubercule bacilli,6 and emulsifying and dispersing substances in medicinal and food products. It has little or no activity as an anti-bacterial agent1 except it has been shown to have an adverse effect on the antibacterial effect of methyl paraben and related compounds. Polysorbates have been reported to be incompatible with alkalis, heavy metal salts, phenols, and tannic acid. They may reduce the activity of many preservatives. | [References]
https://en.wikipedia.org/wiki/Polysorbate_80
http://thegoodhuman.com/what-is-polysorbate-80/
http://www.crodahealthcare.com/home.aspx?s=149&r=344&p=2259
https://pubchem.ncbi.nlm.nih.gov/compound/443315#section=Top
[1] Lee S. Schwartzberg, Rudolph M. Navari. “Safety of Polysorbate 80 in the Oncology Setting.” Advances in Therapy 35 6 (2018): 754–767. |
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