| Identification | More | [Name]
Agar | [CAS]
9002-18-0 | [Synonyms]
AGAR-EPI
MACCONKEY AGAR
MACCONKEY AGAR CS
MAC CONKEY AGAR NO 1
MACCONKEY AGAR NO 1, VEGITONE
MACCONKEY AGAR WITH MUG
MACCONKEY AGAR WITHOUT CRYSTAL VIOLET
MACCONKEY BROMOCRESOL PURPLE BROTH
MACCONKEY BROTH PURPLE
MAC CONKEY MUG AGAR
VEGITONE MACCONKEY AGAR NO 1
agaragarflake
agar-agargum
agaropectin,mixtwithagarose
agarose,mixtwithagaropectin
bengal
bengalgelatin
bengalisinglass
ceylon
ceylonisinglass | [EINECS(EC#)]
232-658-1 | [Molecular Formula]
(C12H18O9)n | [MDL Number]
MFCD00217113 | [MOL File]
9002-18-0.mol | [Molecular Weight]
336.335 |
| Chemical Properties | Back Directory | [Appearance]
white to pale yellow or tan crystalline powder, no odour | [Melting point ]
85-95 °C
| [FEMA ]
2012 | [storage temp. ]
BELOW +15°C
| [solubility ]
H2O: 1.5% with heat
| [form ]
shredded
| [color ]
Brownish yellow | [Odor]
Odorless | [PH]
6.5-6.8 (1.5% in gel, after autoclaving) | [PH Range]
5 - 7 | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Odor Type]
bland | [Water Solubility ]
SOLUBLE IN HOT WATER | [Sensitive ]
Moisture Sensitive & Hygroscopic | [Merck ]
14,184 | [Uses]
Agar is a gum obtained from red seaweeds of the genera gelidium,
gracilaria, and eucheuma, class rhodophyceae. it is a mixture of the
polysaccharides agarose and agaropectin. it is insoluble in cold
water, slowly soluble in hot water, and soluble in boiling water,
forming a gel upon cooling. the gels are characterized as being
tough and brittle, setting at 32–40°c, and melting at 95°c. a rigid,
tough gel can be formed at 0.5%. agar mainly functions in gel for-
mation because of its range between melting and setting tempera-
tures, being used in piping gels, glazes, icings, dental impression
material, and microbiological plating. typical use levels are
0.1–2.0%. | [CAS DataBase Reference]
9002-18-0(CAS DataBase Reference) | [EPA Substance Registry System]
9002-18-0(EPA Substance) |
| Hazard Information | Back Directory | [Chemical Properties]
white to pale yellow or tan crystalline powder, no odour | [Uses]
Substitute for gelatin, isinglass, etc. in making emulsions including photographic, gels in cosmetics, and as thickening agent in foods especially. confectionaries and dairy products; in meat canning; in production of medicinal encapsulations and ointments; as dental impression mold base; as corrosion inhibitor; sizing for silks and paper; in the dyeing and printing of fabrics and textiles; in adhesives. In nutrient media for bacterial cultures. | [General Description]
Tan powder. | [Reactivity Profile]
Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. They exhibit both weak acid and weak base behavior. | [Air & Water Reactions]
Water insoluble. | [Fire Hazard]
Flash point data for this chemical are not available. AGAR AGAR is probably combustible. | [Occurrence]
Agar is found in several species of red marine algae in oceans around the world. | [Definition]
agar: An extract of certain species ofred seaweeds that is used as a gellingagent in microbiological culturemedia, foodstuffs, medicines, andcosmetic creams and jellies. Nutrientagar consists of a broth made frombeef extract or blood that is gelledwith agar and used for the cultivationof bacteria, fungi, and somealgae. | [Production Methods]
Agar is obtained by freeze-drying a mucilage derived from Gelidium
amansii Lamouroux, other species of the same family (Gelidiaceae),
or other red algae (Rhodophyta). | [Agricultural Uses]
Also known as agar, the word agar-agar is of Malaysian
origin. It refers to the red seaweeds belonging to genus
Eucheuma, used widely in Malaysia for making a
gelatinous material.
Agar is a mucilage synthesized by red algae and
stored along with cellulose in the cell wall. It is a dry,
amorphous and gelatine-like extract, devoid of any nonnitrogenous
material from Gelidium and other
agarophytes. The extract is the sulphuric acid ester of a
linear galactan, soluble in hot water but insoluble in cold
water. A 1.5% agar solution can form a firm gel at
around 35℃ (with a melting point above 85℃), the gel
being a mixture of a partially methylated neutral
polysaccharide (agarose) and sulphuric acid ester
(agaropectin) of a linear galactan. The gel is made under
steam pressure or by boiling, and its agar content
depends on the algal species, season and extraction
method.
Agar is manufactured from various algae or seaweeds
called agarophytes, whereas the term agaroidophyte
denotes the red seaweeds that yield a substance
chemically akin to an agar-like substance, but with
different viscosity and gelling properties. The important
agarophytes used for extraction of agar are Acanthopeltis
japonica, Ahnfeltia plicata and species under the genera
Gelidium, Gracilaria and Rerocladia. Other red algae
are Comphylaephora, Eucheuma, Hypnea, Gigartina
and Furcellaria.
Different countries use different red algae for making
agar. For example, Suhria, Gelidium,
Pterocladia, and Ahnfeltia are used in South Africa, the
US, New Zealand and Russia respectively. Often, the
alga carries the name of that country where it is used. For
example, Ceylon agar (or Ceylon moss) refers to the
dried red seaweed Gracilaria lichenoides found mainly in
Sri Lanka, whereas the same alga found along the Indian
coast bordering the Indian Ocean is called Bengal
isinglass. Gracilaria verrucosa in China is
known as Chinese moss, whereas in Japan, agar-agar
made from Gelidium sp. is called Kanten, which means
cold sky, because it was made in cold winter days or high
up in the mountains.
Agar is used for many purposes - as a solidifying
agent in the culture medium used for multiplication of
beneficial bacteria like Azotobacter and Azospirillum
during biofertilizer production, for algal
growth, for canning tuna fish (in Japan), in the sizing of
fabrics, etc. Various grades of agar are used as coating
material for waterproofing paper and cloth, as a glue, as a
cleaning medium for liquids, as a lubricant, in hot
drawing of tungsten wire for electrical lamps (for which a
suspension of powdered graphite in agar gel is used), for
making photographic plates and films, for imparting
gloss and stiffness to leather, and as an adhesive in the
manufacture of plywood. Agar is even used in food
products, for thickening soups, sauces, ice creams,
malted milks, jellies, candies and pastries. Due to its high
temperature tolerance, agar is fovored in food products.
It substitutes pectin for making jellies, jams,
marmalades, etc. and serves as a clarifying agent in the
manufacture of wine, beer and coffee. | [Pharmaceutical Applications]
Agar is widely used in food applications as a stabilizing agent. In
pharmaceutical applications, agar is used in a handful of oral tablet
and topical formulations. It has also been investigated in a number
of experimental pharmaceutical applications including as a
sustained-release agent in gels, beads, microspheres, and tablets.It has also been reported to work as a disintegrant in tablets.
Agar has been used in a floating controlled-release tablet; the
buoyancy in part being attributed to air entrapped in the agar gel
network.It can be used as a viscosity-increasing agent in aqueous
systems. Agar can also be used as a base for nonmelting, and
nondisintegrating suppositories.Agar has an application as a
suspending agent in pharmaceutical suspensions. | [Biochem/physiol Actions]
Bacteriological agar is commonly used as a culture medium for microorganism. It is useful for fermentation process. Agar-agar serves as a preservative in food processing. It also possesses various other applications such as an emulsifier, carrier, lubricant, stabilizer, laxative disintegrant in pharmaceutical and cosmetic industries. Agar-agar is also used in photographic emulsion. | [Safety]
Agar is widely used in food applications and has been used in oral
and topical pharmaceutical applications. It is generally regarded as
relatively nontoxic and nonirritant when used as an excipient.
LD50 (hamster, oral): 6.1 g/kg
LD50 (mouse, oral): 16.0 g/kg
LD50 (rabbit, oral): 5.8 g/kg
LD50 (rat, oral): 11.0 g/kg | [storage]
Agar solutions are most stable at pH 4–10.
Agar should be stored in a cool, dry, place. Containers of this
material may be hazardous when empty since they retain product
residues (dust, solids). | [Incompatibilities]
Agar is incompatible with strong oxidizing agents. Agar is
dehydrated and precipitated from solution by ethanol (95%).
Tannic acid causes precipitation; electrolytes cause partial dehydration
and decrease in viscosity of sols. |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
2
| [RTECS ]
AW7950000
| [F ]
3 | [TSCA ]
Yes | [HS Code ]
13023100 | [Safety Profile]
Mildly toxic by ingestion. When heated to decomposition it emits acrid smoke and fumes. | [Hazardous Substances Data]
9002-18-0(Hazardous Substances Data) | [Toxicity]
LD50 orally in Rabbit: 11000 mg/kg |
| Questions And Answer | Back Directory | [Description]
Agar is a dried, hydrophilic, colloidal polysaccharide complex extracted from the agarocytes of algae of the Rhodophyceae. The structure is believed to be a complex range of polysaccharide chains having alternating a-(1!3) and b-(1!4) linkages. There are three extremes of structure noted: namely neutral agarose; pyruvated agarose having little sulfation; and a sulfated galactan. Agar can be separated into a natural gelling fraction, agarose, and a sulfated nongelling fraction, agaropectin.
Nutrient Agar
| [Chemical Properties]
Agar is produced by some red algae species (Rhodophyceae), especially Gelidium and Gracilaria. Agar contains two polysaccharides - agarose (agaran) and agaropectin. Agarose consists mainly of D-galactose and the 3,6-anhydro form of L-galactose, with small amounts of D-xylose. Some of the D-galactose units are methylated at C-6. The polymer contains alternatingsegments of α(1~3) linked D-galactose units and β (1~4) linked 3,6-anhydro-L-galactose. The main chains of agaropectin are similar, but contain D-glucuronic acid and small amounts of other sugars, including sulphate esters. Agar is not attacked by microorganisms and its strong gel-forming properties make it an ideal matrix for microbial cultures.
| [Regulatory Status]
CoE: n/a
FDA: 21 CFR 150 et. seq., 184.1115, 582.7115; 27 CFR 24.243
FDA (other): Approved for OTC use (21 CFR 310.545); HOC (1992)
JECFA: ADI: Not limited (1973)
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