| Identification | More | [Name]
Manidipine hydrochloride | [CAS]
89226-75-5 | [Synonyms]
1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester hydrochloride
MANIDIPINE DIHYDROCHLORIDE
MANIDIPINE HYDROCHLORIDE
4-(diphenylmethyl)-1-piperazinyl)ethylmethylester,dihydrochloride
cv-4093dihydrochlorde
franidipinehydrochloride
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester, dihydrochloride (9CI)
Calslot
CV 4093
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester hydrochloride
CV-4093(2HCl) | [EINECS(EC#)]
680-304-3 | [Molecular Formula]
C35H40Cl2N4O6 | [MDL Number]
MFCD00896434 | [Molecular Weight]
683.62 | [MOL File]
89226-75-5.mol |
| Chemical Properties | Back Directory | [Melting point ]
157-163°; mp 174-180°; mp 167-170° | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
Soluble in DMSO (>25 mg/ml) | [form ]
solid | [color ]
White | [Water Solubility ]
Soluble in DMSO. Slightly soluble in water and ethanol
/n | [Merck ]
14,5743 | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. | [InChIKey]
UFIXGLLGFBWKAV-UHFFFAOYSA-N | [SMILES]
C1(C)NC(C)=C(C(OCCN2CCN(C(C3=CC=CC=C3)C3=CC=CC=C3)CC2)=O)C(C2=CC=CC([N+]([O-])=O)=C2)C=1C(OC)=O.[H]Cl | [CAS DataBase Reference]
89226-75-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [RIDADR ]
UN 2811 6.1/PG III | [RTECS ]
US7975300 | [HS Code ]
2933.59.8000 | [HazardClass ]
6.1 | [PackingGroup ]
III | [Toxicity]
LD50 in male, female mice, male, female rats (mg/kg): 387, 340, 222, 199 s.c.; 62.2, 68.0, 66.5, 48.8 i.p.; 190, 171, 247, 156 orally (Chiba) |
| Hazard Information | Back Directory | [Description]
Manidipine (89226-75-5) is a clinically useful antihypertensive.1,2 It is an inhibitor of L- and T-type calcium channels with high selectivity for vasculature.? Manidipine has recently been found to be an inhibitor (IC50 = 4.8 μM) of the SARS-CoV-2 main protease, 3CLpro.3 It also acts as an early entry inhibitor of human cytomegalovirus (EC50 = 3.57 μM) via inhibition of the Immediate-Early 2 (IE2) protein.4 | [Uses]
aldosterone antagonist | [Uses]
Manidipine Dihydrochloride is a metabolite of Manidipine (M16400), a dihydropyridine calcium channel blocker that exhibits antihypertensive properties. | [Definition]
ChEBI: Manidipine dihydrochloride is a diarylmethane. | [References]
Kakihana et al. (1988), Antihypertensive effect of CV-4093·2HCl, a new calcium antagonist, in three rat models of hypertension; Jpn. J. Pharmacol., 48 223
McKeage (2004), Manidipine: a review of its use in the management of hypertension; Drugs, 64 1923
Ghahremanpour et al. (2020), Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2; ACS Med. Chem. Lett., 11 2526
Mercorelli et al. (2018), Repurposing the clinically approved calcium antagonist manidipine dihydrochloride as a new early entry inhibitor of human cytomegalovirus targeting the Immediate-Early 2 (IE2) protein; Antiviral Res., 150 130 |
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