| Identification | More | [Name]
2,4-Dihydroxyacetophenone | [CAS]
89-84-9 | [Synonyms]
1-ACETYL-2,4-DIHYDROXYBENZENE
2',4'-DIHYDROXYACETOPHENONE
2,4-DIHYDROXYACETOPHENONE
2,4-DIHYDROXY ACETPHENONE
4-ACETYLRESORCINOL
AKOS 90593
AKOS BBS-00004294
RESACETOPHENONE
1-(2,4-dihydroxyphenyl)-ethanon
1-(2,4-dihydroxyphenyl)ethanone
1-(2,4-Dihydroxyphenyl)-ethanone
1-Acetylbenzene-2,4-diol
2’,4’-dihydroxy-acetophenon
4-Acetyl-1,3-benzenediol
4-acetyl-resorcino
Acetophenone, 2',4'-dihydroxy-
beta-Resacetophenone
b-Resacetophenone
Resoacetophenone
Resorcinol, 4-acetyl- | [EINECS(EC#)]
201-945-3 | [Molecular Formula]
C8H8O3 | [MDL Number]
MFCD00002279 | [Molecular Weight]
152.15 | [MOL File]
89-84-9.mol |
| Chemical Properties | Back Directory | [Appearance]
yellow-brown to reddish-brown fine cryst. powder | [Melting point ]
143-144.5 °C(lit.)
| [Boiling point ]
234.6°C (rough estimate) | [density ]
1.18 g/mL at 25 °C(lit.)
| [refractive index ]
1.4945 (estimate) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Crystalline Powder or Crystals | [pka]
7.96±0.18(Predicted) | [color ]
Off-white to pink to brown | [PH]
5 (1g/l, H2O, 20℃) | [Sensitive ]
Moisture Sensitive | [Merck ]
14,8140 | [BRN ]
1282505 | [InChIKey]
SULYEHHGGXARJS-UHFFFAOYSA-N | [LogP]
1.480 (est) | [CAS DataBase Reference]
89-84-9(CAS DataBase Reference) | [NIST Chemistry Reference]
Ethanone, 1-(2,4-dihydroxyphenyl)-(89-84-9) | [EPA Substance Registry System]
89-84-9(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
2
| [RTECS ]
AM7525000
| [Hazard Note ]
Irritant | [TSCA ]
Yes | [HS Code ]
29145000 | [Safety Profile]
Moderately toxic by
ingestion. Experimental reproductive
effects. A severe eye irritant. When heated
to decomposition it emits acrid smoke and
irritating fumes. |
| Hazard Information | Back Directory | [Chemical Properties]
2,4-Dihydroxyacetophenone(89-84-9) appears as a yellow-brown to reddish-brown fine crystalline powder. It slowly decomposes in water and can dissolve in hot alcohol, pyridine, and glacial acetic acid. In contrast, it is nearly insoluble in ether, benzene, and chloroform. A reaction with iron chloride causes it to adopt a red hue. | [Uses]
2,4-Dihydroxyacetophenone is used as intermediate for pharmaceuticals.
| [Uses]
Reagent for iron as a 10% alcoholic solution. A red color is obtained with ferric ions in slightly acid solution: Cooper, Ind. Eng. Chem. Anal. Ed. 9, 334 (1937). | [Definition]
ChEBI: A dihydroxyacetophenone that is acetophenone carrying hydroxy substituents at positions 2' and 4'. | [Preparation]
Preparation by reaction of acetic acid on resorcinol,
with zinc chloride (Nencki reaction) (94%)
with boron trifluoride
with Amberlite IR-120 (a cation exchange resin, sulfonic acid type) (87%)
with polyphosphoric acid (63%)
with 70% perchloric acid (33%). | [Synthesis Reference(s)]
Journal of the American Chemical Society, 70, p. 428, 1948 DOI: 10.1021/ja01181a521 | [Synthesis]
2,4-Dihydroxyacetophenone is obtained by the acetylation of resorcinol and acetic acid. In addition, it can also be obtained by reacting resorcinol with chloroacetyl or acetic anhydride in the presence of zinc chloride. | [target]
Phospholipase (e.g. PLA) |
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