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ChemicalBook--->CAS DataBase List--->88519-57-7

88519-57-7

88519-57-7 Structure

88519-57-7 Structure
IdentificationMore
[Name]

N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE
[CAS]

88519-57-7
[Synonyms]

W-13
W-13 HYDROCHLORIDE
OMEGA-13 HYDROCHLORIDE
N-(4-AMINOBUTYL)-5-CHLORO-2- &
W-13 HYDROCHLORIDE CALMODULIN ANTAGONIST
W-13, Hydrochloride - CAS 88519-57-7 - Calbiochem
N-(4-aminobutyl)-5-chloro-2-*naphthalenesulfonami
N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HCL
4-[(5-chloro-2-naphthalenyl)sulfonylamino]butylammonium
N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE
N-(4-Aminohexyl)-5-chloro-2-naphthalenesulfonamide hydrochloride
N-(4-AMinobutyl)-5-chloronaphthalene-2-sulfonaMide Hydrochloride
N-(4-Aminobutyl)-5-chloronaphthalene-2-sulphonamide hydrochloride
N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENE SULPHONAMIDE, HYDROCHLORIDE
N-(4-Aminobutyl)-5-chloronaphthalene-2-sulfonamide Hydrochloride >
N-(4-AMinobutyl)-5-chloro-2-naphthalenesulfonaMide Monohydrochloride
2-NaphthalenesulfonaMide, N-(4-aMinobutyl)-5-chloro-, Monohydrochloride
N-(4-Aminobutyl)-5-chloronaphthalene-2-sulfonamide Hydrochloride
(+)-5-Hydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-7-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
[Molecular Formula]

C14H18Cl2N2O2S
[MDL Number]

MFCD00058030
[Molecular Weight]

349.28
[MOL File]

88519-57-7.mol
Chemical PropertiesBack Directory
[Appearance]

Beige Solid
[Melting point ]

241-243°C
[storage temp. ]

2-8°C
[solubility ]

H2O: Stock solutions of 5 mM are recommended. These stocks should be stable for up to 6 months when stored at 4?#x00b0;C.soluble
[form ]

powder
[color ]

white
[Water Solubility ]

water: 35mg/mL
[Usage]

Calmodulin antagonist that binds to calmodulin and inhibits calcium-ion-calmodulin-regulated activities, including phosphodiesterase activation and myosin light chain kinase
[CAS DataBase Reference]

88519-57-7(CAS DataBase Reference)
Safety DataBack Directory
[Safety Statements ]

S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
[WGK Germany ]

3
[HS Code ]

2935.90.9500
Hazard InformationBack Directory
[Description]

W-13 is a naphthalenesulfonamide derivative that acts as a potent antagonist of calmodulin (IC50 = 22 μM) and is widely used to investigate Ca2+/calmodulin-regulated enzyme activities.
[Chemical Properties]

Beige Solid
[Uses]

Calmodulin antagonist that binds to calmodulin and inhibits calcium-ion-calmodulin- regulated activities, including phosphodiesterase activation and myosin light chain kinase127,  it  is widely used to investigate Ca2+/calmodulin-regulated enzyme activities.
[Uses]

W-13 is a naphthalenesulfonamide derivative that acts as a potent antagonist of calmodulin (IC50 = 22 μM) and is widely used to investigate Ca2+/calmodulin-regulated enzyme activities.
[Definition]

ChEBI:N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide hydrochloride is a hydrochloride salt prepared from equimolar amounts of N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide and hydrogen chloride. It contains a N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide(1+).
[Biological Activity]

Calmodulin antagonist (inhibits calmodulin activated PDE activity with an IC 50 of 68 μ M). Inhibits growth of tamoxifen-resistant breast cancer cells.
[Biochem/physiol Actions]

W-13 has also been shown to inhibit the transcytosis of IgA, recycling of transferrin and overall alter the endocytic pathway in Madin-Darby canine kidney cells.
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE(88519-57-7)1HNMR
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

88519-57-7(sigmaaldrich)
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