Identification | Back Directory | [Name]
P-5091 | [CAS]
882257-11-6 | [Synonyms]
P5091 P-5091 P 5091 CS-726 P005091 P-005091 P 005091 P5091, >=98% P005091(P5091) P5091 (P005091) P-5091 USP/EP/BP P5091; P-005091; P 005091; P 5091; P-5091 1-[5-[(2,3-Dichlorophenyl)thio]-4-n-itro-2-thienyl]ethanone 1-(5-(2,3-dichlorophenylthio)-4-nitrothiophen-2-yl)ethanone 1-[5-(2,3-dichlorophenyl)sulfanyl-4-nitro-2-thienyl]ethanone Ethanone, 1-[5-[(2,3-dichlorophenyl)thio]-4-nitro-2-thienyl]- 1-[5-(2,3-Dichloro-phenylsulfanyl)-4-nitro-thiophen-2-yl]-ethanone 1-[5-[(2,3-Dichlorophenyl)thio]-4-nitro-2-thienyl]-ethanone P005091 | [Molecular Formula]
C12H7Cl2NO3S2 | [MDL Number]
MFCD00123202 | [MOL File]
882257-11-6.mol | [Molecular Weight]
348.22 |
Chemical Properties | Back Directory | [Boiling point ]
452.4±45.0 °C(Predicted) | [density ]
1.60±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble10mg/mL, clear | [form ]
powder | [color ]
light yellow to dark yellow | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
Hazard Information | Back Directory | [Description]
P5091 (882257-11-6) is a selective inhibitor of the ubiquitin-specific protease USP7 ( IC50=4.2 μM).1,2 Induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.1?P5091 displays antiangiogenic activity in vivo.2?Cell permeable | [Uses]
P005091 is a selective dual inhibitor of the cancer-related deubiquitylating proteases USP7 and USP47. | [Biochem/physiol Actions]
P5091 plays an important role in ovarian cancer, as it can prevent the growth of cells and can promote necrosis and apoptosis. | [storage]
Store at 4°C | [References]
1) Chauhan et al. (2012), A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance; Cancer Cell, 22 345
2) Weinstock et al. (2012), Selective dual inhibitors of the cancer-related deubiquitylating proteases USP7 and USP47; ACS Med. Chem. Lett., 3 789 |
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