| Identification | Back Directory | [Name]
1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)- | [CAS]
881674-56-2 | [Synonyms]
5-(2-FL
Vonorazan
e-3-carbaL
)-1H-pyrroL
Vonoprazan-1
Vonoprazan-023
VONOPRAZAN IST-1
TAK438 Impurity 54
TAK438 Intermediate
Vonolazan impurity 1
TAK438 Impurity 54 CRS
5-(2-Fluorophenyl)pyrrole-3-carbaldehyde
5-(2-Fluorophenyl)-1H-pyrrole-3-carbal...
5-(2-Fluorophenyl)pyrrole-3-carboxaldehyde
5-(2-Fluorophenyl)-1H-pyrrol-3-carbaldehyde
1-[(2S) -2-pyrrolidinecarbonyl] -pyrrolidine
5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde
TAK-438( Vonoprazan fumarate) intermediate 3
5-(2-fluorophenyl)-1H-Pyrrole-3-carboxaldehy
5-(2-Fluorophenyl)-1H-pyrrole-3-carboxaldehyde
1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-
5 - (2-fluorophenyl) - 1h-pyrrole-3-formaldehyde
1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1H-pyrrole-
1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde | [EINECS(EC#)]
809-913-6 | [Molecular Formula]
C11H8FNO | [MDL Number]
MFCD11875867 | [MOL File]
881674-56-2.mol | [Molecular Weight]
189.186 |
| Chemical Properties | Back Directory | [Melting point ]
133 °C | [Boiling point ]
370.6±32.0 °C(Predicted) | [density ]
1.270±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
14.77±0.50(Predicted) | [color ]
Light Brown to Brown | [Stability:]
Hygroscopic | [InChI]
InChI=1S/C11H8FNO/c12-10-4-2-1-3-9(10)11-5-8(7-14)6-13-11/h1-7,13H | [InChIKey]
MQULPEUCGKEHEG-UHFFFAOYSA-N | [SMILES]
N1C(C2=CC=CC=C2F)=CC(C=O)=C1 |
| Hazard Information | Back Directory | [Description]
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde is an ether. It can be used to prepare vonoprazan fumarate, which is a potent orally active potassium-competitive acid blocker (P-CAB) with antisecretory activity. It is used in the study of acid-related diseases. | [Chemical Properties]
Light orange to Yellow to Green powder to crystal. | [Uses]
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde acts as a reagent in the synthetic preparation of novel pyrrole derivatives as potassium-competitive acid blocker (P-CAB). | [Application]
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde is a potassium ion-competitive acid blocker used in therapy Acid-related diseases, gastric ulcer, duodenal ulcer, reflux esophagitis, etc. | [Definition]
The 5-(2-fluorophenyl) -1H-pyrrole-3-formaldehyde is an important intermediate of Voranolan fumarate, a competitive potassium ion acid blocker. Voranolan fumarate treats gastric ulcers, duodenal ulcers, reflux esophagitis, etc. 5-(2-fluorophenyl) -1H-pyrrole-3-formaldehyde can be synthesized in one pot using 2-(2-fluorobenzoyl)malononitrile as raw material. | [Preparation]
Synthesis of 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde: Using pyrrole as raw material, after being protected by N-alkylation of triisopropylsilyl chloride, it is then reacted with Vilsmeier reagent to obtain 1H-Pyrrole-3-carbaldehyde, which is then purified by N-bromosuccinimide (NBS) bromination and 2-fluorophenylboronic acid for Suzuki coupling reaction to obtain crude 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde, which was purified with toluene. The total yield was 35.5%. | [Hazard]
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde has acute toxin effects and is a skin and eye irritant. |
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