| Identification | More | [Name]
2-Nitrochlorobenzene | [CAS]
88-73-3 | [Synonyms]
1-CHLORO-2-NITROBENZENE
1-NITRO-2-CHLORINE BENZENE
2-Chloro-1-nitrobenzene
2-CHLORONITROBENZENE
2-cnb
2-NITROCHLOROBENZENE
O-CHLORONITROBENZENE
O-NITROCHLOROBENZENE
ORTHO NITROCHLOROBENZENE
1-chloro-2-nitro-benzen
1-Nitro-2-chlorobenzene
benzene,1-chloro-2-nitro-
chloro-1nitro-2benzene
Chloro-o-nitrobenzene
Nitrochlorobenzene, o-
Nitrochlorobenzene, ortho
ONCB
o-nitrochlorobenzene,[liquid]
Ortho Nitrochlorobenzene [ONCB]
2-Chluoronitrobenzene | [EINECS(EC#)]
201-854-9 | [Molecular Formula]
C6H4ClNO2 | [MDL Number]
MFCD00007061 | [Molecular Weight]
157.55 | [MOL File]
88-73-3.mol |
| Chemical Properties | Back Directory | [Appearance]
yellow solid with a characteristic odour | [Melting point ]
31-33 °C (lit.) | [Boiling point ]
246 °C (lit.) | [density ]
1.348 g/mL at 25 °C(lit.)
| [vapor density ]
5.4 (vs air)
| [vapor pressure ]
0.04 mm Hg ( 25 °C)
| [refractive index ]
1.5520 (estimate) | [Fp ]
>230 °F
| [storage temp. ]
Store below +30°C. | [solubility ]
alcohol: soluble | [form ]
Fused Crystalline Mass | [color ]
Yellow | [PH]
6 (0.4g/l, H2O, 20℃) | [Stability:]
Stable. Combustible. Incompatible with strong oxidizing agents, reducing agents, strong bases, alkali metals. | [explosive limit]
1.15-13.1%(V) | [Water Solubility ]
0.43 g/L (20 ºC) | [Merck ]
14,2151 | [BRN ]
509273 | [InChIKey]
BFCFYVKQTRLZHA-UHFFFAOYSA-N | [Uses]
Intermediate, especially for dyes. | [CAS DataBase Reference]
88-73-3(CAS DataBase Reference) | [IARC]
2B (Vol. 65, 123) 2020 | [NIST Chemistry Reference]
Benzene, 1-chloro-2-nitro-(88-73-3) | [EPA Substance Registry System]
o-Chloronitrobenzene (88-73-3) |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
R22:Harmful if swallowed.
R24:Toxic in contact with skin.
R52:Harmful to aquatic organisms.
R53:May cause long-term adverse effects in the aquatic environment.
R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S60:This material and/or its container must be disposed of as hazardous waste .
S38:In case of insufficient ventilation, wear suitable respiratory equipment . | [RIDADR ]
UN 1578 6.1/PG 2
| [WGK Germany ]
2
| [RTECS ]
CZ0875000
| [Autoignition Temperature]
500 °F | [Hazard Note ]
Toxic | [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
II | [HS Code ]
29049085 | [Safety Profile]
Suspected carcinogen
with experimental carcinogenic and
neoplastigenic data. Poison by ingestion,
skin contact, and probably inhalation.
Combustible when exposed to heat or
flame. To fight fire, use water, foam.
Potentially explosive reaction with ammonia
at 160℃/30 bar. When heated to
decomposition it emits toxic fumes of Cl-,
NOx, and phosgene. See also other
chloronitrobenzene entries and NITRO COMPOUNDS of AROMATIC
HYDROCARBONS. | [Hazardous Substances Data]
88-73-3(Hazardous Substances Data) |
| Hazard Information | Back Directory | [General Description]
Yellow crystals with an aromatic odor. Sinks in water. | [Reactivity Profile]
O-NITROCHLOROBENZENE is incompatible with strong bases and strong oxidizing agents. O-NITROCHLOROBENZENE, [LIQUID] will react with ammonia. | [Air & Water Reactions]
This chemical may be sensitive to prolonged exposure to air and light. Insoluble in water. | [Hazard]
Toxic by inhalation and ingestion. Combustible. Questionable carcinogen. | [Health Hazard]
INHALATION: Headache, languour, anemia. Irritation of nose and throat, cyanosis, shallow respiration, convulsions, and coma. EYES: Irritation. SKIN: Irritation. INGESTION: Forms methemoglobin giving rise to cyanosis and blood changes. | [Chemical Properties]
yellow solid with a characteristic odour | [Definition]
ChEBI: 1-chloro-2-nitrobenzene is a C-nitro compound that is nitrobenzene in which one of the ortho- hydrogens has been replaced by chlorine. It is a C-nitro compound and a member of monochlorobenzenes. | [Production Methods]
Nitration of chlorobenzene with mixed acid (30/56/14) typically gives an isomer mix in 98 % yield consisting of 34 – 36 % 2-Nitrochlorobenzene, 63 – 65 % 4- chloronitrobenzene, and only ca. 1 % 3- chloronitrobenzene. The ortho – para ratio of about 0.55 is in sharp contrast to the 1.6 obtained with nitrotoluene isomers. As with the nitration of toluene, much work has been done on isomer control so that the producer might have some flexibility towards the balance of isomer demand. Although no major change in ratio has been achieved, the situation is better for nitrochlorobenzene than nitrotoluenes, because the favored isomer is in much greater demand. In further contrast to the nitration of toluene, the nitration of chlorobenzene in the presence of phosphoric acid decreases the proportion of 4-Nitrochlorobenzene, and the use of phosphoric acid in the presence of a transition-metal catalyst is said to increase the ortho – para ratio to ca. 0.8. | [Flammability and Explosibility]
Notclassified | [Purification Methods]
Crystallise it from EtOH, MeOH or pentane (charcoal). [Beilstein 5 IV 721.] |
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