854601-60-8

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854601-60-8 Structure

Identification	Back Directory
[Name] 3,6,9,12,15,18,21,24,27,30,33-Undecaoxatetratriacontan-1-amine
[CAS] 854601-60-8
[Synonyms] m-PEG11-amine 3,6,9,12,15,18,21,24,27,30,33-Undecaoxatetratriacontan-1-amine 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine
[Molecular Formula] C23H49NO11
[MDL Number] MFCD27977521
[MOL File] 854601-60-8.mol
[Molecular Weight] 515.64

Chemical Properties	Back Directory
[Boiling point ] 551.9±45.0 °C(Predicted)
[density ] 1.070±0.06 g/cm3(Predicted)
[form ] Solid-Liquid Mixture
[pka] 8.74±0.10(Predicted)
[color ] Colorless to off-white

Safety Data	Back Directory
[Symbol(GHS) ] GHS07
[Signal word ] Warning
[Hazard statements ] H302-H315-H319-H335
[Precautionary statements ] P261-P305+P351+P338

Hazard Information

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[Description]

m-PEG11-amine is a water soluble PEG linker containing an amino group. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases solubility in aqueous media.

[Biological Activity]

M-PEG11-Amino is a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs). It is also a PEG-based PROTAC linker that can be used for PROTAC synthesis.

[in vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins

[target]

Cleavable

PEGs

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