| Identification | More | [Name]
BAPTA | [CAS]
85233-19-8 | [Synonyms]
1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'-TETRAACETIC ACID
1,2-BIS-(O-AMINOPHENOXY)-ETHANE-N,N,N',N'-TETRAACETIC ACID
BAPTA
ETHYLENEDIOXYBIS(O-PHENYLENENITRILO)TETRAACETIC ACID
1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'-TETRAACETI
1,2-Bis-(2-Aminophenoxy) Ethane-N,N,N,-Tetra Acetic Acid
BAPTA (1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N'',N''-TETRAACETIC ACID)
BAPTA, Ethylenedioxybis(o-phenylenenitrilo)tetraacetic acid, 2,2μ-(Ethylenedioxy)dianiline-N,N,Nμ,Nμ-tetraacetic acid
BAPTA, Ethylenedioxybis(o-phenylenenitrilo)tetraacetic acid
1,2-BIS(2-AMINOPHENOXY)-ETHANE-N,N,N',N'-TETRAACETIC ACID 97%
2,2',2'',2'''-[Ethylenebisoxybis(2,1-phenylenenitrilo)]tetrakisacetic acid
Ethylenebis(oxy-2,1-phenylenenitrilo)tetraacetic acid | [Molecular Formula]
C22H24N2O10 | [MDL Number]
MFCD00036255 | [Molecular Weight]
476.43 | [MOL File]
85233-19-8.mol |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
177-179 °C | [Boiling point ]
575.89°C (rough estimate) | [density ]
1.4482 (rough estimate) | [refractive index ]
1.6500 (estimate) | [RTECS ]
MC0423000 | [storage temp. ]
2-8°C
| [solubility ]
Soluble in dimethyl sulfoxide | [form ]
Powder | [pka]
1.40±0.10(Predicted) | [color ]
White to off-white | [Water Solubility ]
Soluble in water and sodium bicarbonate. | [Usage]
A highly selective calcium chelating reagent | [λmax]
209 nm, 254 nm, 203 nm, 274 nm | [Merck ]
14,957 | [BRN ]
5192406 | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. | [Biological Applications]
Calcium indicators; zinc indicators; treating acute cell death,cerebral infarction,myocardial infarction,hepatonecrosis,kidney ischemic necrosis,necrotizing pancreatitis,amyloidosis,atherosclerosis,diseases characteriz | [InChIKey]
FTEDXVNDVHYDQW-UHFFFAOYSA-N | [CAS DataBase Reference]
85233-19-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [HS Code ]
29225090 |
| Hazard Information | Back Directory | [Description]
BAPTA free acid (85233-19-8) is a selective extracellular Ca2+ chelator. It is a widely used calcium sponge for chelating Ca2+?outside of intact cells.1 It’s a useful tool to probe the involvement of extracellular Ca2+ in cellular signaling.2,3 Non-cell-permeable. | [Chemical Properties]
White Solid | [Uses]
As calcium chelator; 19F labelled forms for measurement of intracellular calcium. | [Uses]
BAPTA is a highly selective calcium chelating reagent. Lipophilic diesters of the chelating agent 1,2-Bis(2 aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA) are used for inhibition of proteolytic activities of certain metalloproteinases, calpain and TACE. | [Uses]
Highly selective calcium chelating reagent. Suitable for the spectrophotometric monitoring of Ca2+ levels. | [Definition]
ChEBI: A polyamino carboxylic acid in which bis(carboxymethyl)nitrilo groups are bonded to C-2 and C-2' of 1,1'-[ethane-1,2-diylbis(oxy)]dibenzene. | [General Description]
In nature 1,2-Bis(2-Aminophenoxy)ethane-N,N,N′,N′-tetra acetic acid (BAPTA) is a main metabolic product of BAPTA -AM (BAPTA-tetra(actoxymethyl ester), a neuro protective agent in cerebral ischemia, in rats.BAPTA is an intercellular Ca2+ chelator. | [Biological Activity]
Selective calcium chelator. | [storage]
Store at -20°C | [References]
1) Munoz et al. (2015), Different Stress-Induced Calcium Signatures Are Reported by Aequorin-Mediated Calcium Measurements in Living Cells of Aspergillus fumigatus; PLoS One, 10(9) e0138008
2) Wozniak et al. (2017), Extracellular Ca2+ is Required for Fertilization in the African Clawed Frog, Xenopus laevis; PLoS One, 12(1) e0170405
3) Didiasova et al. (2015), STIM1/ORAI1-mediated Ca2+ Influx Regulates Enolase-1 Exteriorization; J. Biol. Chem., 290 11983 |
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