| Identification | More | [Name]
Lorazepam | [CAS]
846-49-1 | [Synonyms]
7-CHLORO-5-[2-CHLOROPHENYL]-1,3-DIHYDRO-3-HYDROXY-2H-1,4-BENZODIAZEPIN-2-ONE
ATIVAN
AURORA KA-7219
EMOTIVAL
LORAX
(+/-)-LORAZEPAM
LORAZEPAM
LORSILAN
WY 4036
(+-)-lorazepammethanolsolution
1,4-benzodiazepin-2-one,7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2
2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-
7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one
7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one
7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one
Almazine
delormetazepam
demethyllormetazepam
norlormetazepam
o-Chlorooxazepam | [EINECS(EC#)]
212-687-6 | [Molecular Formula]
C15H10Cl2N2O2 | [MDL Number]
MFCD00063406 | [Molecular Weight]
321.16 | [MOL File]
846-49-1.mol |
| Chemical Properties | Back Directory | [Appearance]
White Crystalline Solid | [Melting point ]
166-168°C | [Boiling point ]
533.8±50.0 °C(Predicted) | [density ]
1.4835 (rough estimate) | [refractive index ]
1.6070 (estimate) | [Fp ]
11 °C | [storage temp. ]
−20°C | [solubility ]
Practically insoluble in water, sparingly soluble in ethanol (96 per cent), sparingly soluble or slightly soluble in methylene chloride. | [pka]
pK1 1.3; pK2 11.5(at 25℃) | [Water Solubility ]
54mg/L(temperature not stated) | [Usage]
An anxiolytic, and anticonvulsant.
Controlled substance (depressant) | [BCS Class]
1 | [Stability:]
hygroscopic | [CAS DataBase Reference]
846-49-1(CAS DataBase Reference) | [NIST Chemistry Reference]
Lorazepam(846-49-1) | [EPA Substance Registry System]
846-49-1(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,T,F | [Risk Statements ]
R63:Possible risk of harm to the unborn child.
R39/23/24/25:Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed .
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R11:Highly Flammable. | [Safety Statements ]
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S16:Keep away from sources of ignition-No smoking . | [RIDADR ]
UN 1230 3/PG 2 | [WGK Germany ]
3
| [RTECS ]
DF0350000
| [HS Code ]
2933910000 | [Toxicity]
LD50 in mice, rats (mg/kg): 3178, >5000 orally (Owen) |
| Hazard Information | Back Directory | [Chemical Properties]
White Crystalline Solid | [Originator]
Tavor,Wyeth,Italy,1972 | [Uses]
An anxiolytic, and anticonvulsant.
Controlled substance (depressant) | [Definition]
ChEBI: Lorazepam is a benzodiazepine. | [Manufacturing Process]
The starting material was 2-amino-2',5-dichlorobenzophenone which was
reacted with hydroxylamine and then with chloroacetyl chloride. The
intermediate thus obtained is reacted with methylamine and then with acetic
anhydride.
To a slightly warm suspension of 3-acetoxy-7-chloro-5-(o-chlorophenyl)-1,3-
dihydro-2H-1,4-benzodiazepin-2-one thus obtained was added 4N sodium
hydroxide solution with stirring. All the solid dissolved and soon a thick white
solid precipitated out. The solid was filtered, washed well with water and
recrystallized from ethanol. The product was isolated as a solvate with 1 mol
of ethanol. When heated it loses the ethanol of solvation and melts at 166°C
to 168°C. | [Brand name]
Ativan (Baxter Healthcare); Ativan
(Biovail); Loraz (Quantum Pharmics). | [Therapeutic Function]
Tranquilizer | [General Description]
Lorazepam, 7-chloro-5-(2-chlorophenyl)-3-dihydro-3-hydroxy-2H-1,4-benzodiazepine-2-one(Ativan), is the 2'-chloro derivative of oxazepam. In keepingwith overall SARs, the 2'-chloro substituent increases activity.As with oxazepam, metabolism is relatively rapid anduncomplicated because of the 3-hydroxyl group in the compound.Thus, it also has short half-life (2–6 hours) and similarpharmacological activity. | [Biological Activity]
Ligand at the GABA A receptor benzodiazepine modulatory site. Anxiolytic, anticonvulsant and sedative/hypnotic agent. |
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