| Identification | More | [Name]
1-Indanone | [CAS]
83-33-0 | [Synonyms]
1H-INDEN-1-ONE, 2,3-DIHYDRO-
1-HYDRINDONE
1-HYDROINDONE
1-INDANONE
1-KETOHYDRINDENE
1-OXOHYDRINDENE
1-OXOINDAN
1-OXOINDANE
2,3-Dihydro-1H-inden-1-one
2,3-DIHYDROINDEN-1-ONE
A-HYDRINDONE
AKOS 92310
ALPHA-HYDRINDON
ALPHA-HYDRINDONE
INDAN-1-ONE
INDANONE
INDANONE(1-)
1-Indone
2,3-dihydro-1h-inden-1-on
2,3-Dihydro-1-indanone | [EINECS(EC#)]
201-470-1 | [Molecular Formula]
C9H8O | [MDL Number]
MFCD00003785 | [Molecular Weight]
132.16 | [MOL File]
83-33-0.mol |
| Chemical Properties | Back Directory | [Appearance]
Pale yellow liquid | [Melting point ]
38-40 °C(lit.)
| [Boiling point ]
243-245 °C(lit.)
| [density ]
1.103 g/mL at 25 °C(lit.)
| [refractive index ]
1.5610 (estimate) | [Fp ]
233 °F
| [storage temp. ]
Store below +30°C. | [solubility ]
6.5g/l | [form ]
Crystalline Mass | [color ]
Light yellow to brown | [Odor]
Rather weak, woody and somewhat medicinal odor with an incense-like undertone. | [biological source]
mouse | [Odor Threshold]
0.0088ppm | [Water Solubility ]
6.5 g/L (20 C) | [Detection Methods]
GC,NMR | [BRN ]
507957 | [Stability:]
Light sensitive | [InChIKey]
QNXSIUBBGPHDDE-UHFFFAOYSA-N | [CAS DataBase Reference]
83-33-0(CAS DataBase Reference) | [NIST Chemistry Reference]
1H-Inden-1-one, 2,3-dihydro-(83-33-0) | [EPA Substance Registry System]
1H-Inden-1-one, 2,3-dihydro- (83-33-0) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [Autoignition Temperature]
525 °C | [Hazard Note ]
Irritant | [TSCA ]
Yes | [HS Code ]
29143900 |
| Hazard Information | Back Directory | [Chemical Properties]
Pale yellow liquid | [Uses]
1-Indanone is an oxidation product of Indan, a component of fuels, solvents, and varnishes. 1-Indanone is also a metabolite of Thalidomide that has been shown to inhibit the attachment of tumor cells to concanavalin A coated plastic surfaces. | [Definition]
ChEBI: An indanone that consists of 2,3-dihydro-1H-indene substituted by an oxo group at position 1. | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 54, p. 1144, 1989 DOI: 10.1021/jo00266a028
Journal of the American Chemical Society, 99, p. 4822, 1977 DOI: 10.1021/ja00456a048
Tetrahedron Letters, 27, p. 3139, 1986 DOI: 10.1016/S0040-4039(00)84736-X | [Biological Activity]
Indoleamine 2,3 dioxygenase (IDO) 1 plays an important role in the metabolism of tryptophan and in immune regulation. Removal of IDO1 results in attenuated contact hypersensitivity (CHS) responses. | [Synthesis]
1-Indanone is produced by cyclization of be{a-Phenylpropionyl chloride in Benzene. |
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